Patients
Current Clinical Trials: MORF-057
We are conducting the EMERALD clinical trials of MORF-057 in patients suffering from ulcerative colitis, a common form of IBD.
Learn more about MORF-057
EMERALD-1

The EMERALD-1 phase 2a study of MORF-057 in patients with moderate to severe ulcerative colitis is fully enrolled and currently in the maintenance phase for patients participating in the study.

EMERALD-2

The global EMERALD-2 phase 2b study of MORF-057 in patients with moderate to severe ulcerative colitis is open and enrolling. For more information, please see the national clinical trial listing or request information from our clinical affairs team at clinicaltrials@morphictx.com

Advocacy
We are proud to support groups that advocate for patients suffering from IBD, including the Crohn’s and Colitis Foundation
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Integrin Partnership: Janssen

Morphic entered a research partnership with Janssen in 2019 to discover inhibitors of undisclosed integrin targets. In 2021, this partnership was expanded to include an antibody activator of an integrin target, extending the application of Morphic’s knowledge of integrin biology into modalities beyond small molecules. The antibody activator program is the focus of our collaboration with Janssen today.

Undisclosed Targets

Morphic is leveraging the MInT Platform to discover therapeutically relevant small molecule inhibitors of targets across the integrin family to treat autoimmune diseases, cancer and fibrotic diseases.

Undisclosed Target for Pulmonary Arterial Hypertension

Morphic is deploying the MInT Platform to create small molecule inhibitors of an undisclosed integrin target for evaluation as a potential treatment for pulmonary arterial hypertension (PAH). PAH is a devastating, usually fatal disease characterized by elevated mean pressures in the pulmonary artery and associated with lung and heart dysfunction. Morphic’s PAH program is in preclinical development.

αvβ8

Morphic is developing small molecule inhibitors of the integrin αvβ8 through a combination immuno-oncology approach for the treatment of solid tumors as well as potential additional indications. αvβ8 is known to activate selective isoforms of TGF-β and Morphic has demonstrated that αvβ8 inhibition can potentiate immune checkpoint blockade and potentially drive responses in checkpoint refractory tumors. Morphic’s αvβ8 inhibitors are in preclinical development.

Next Gen α4β7 Inhibitors

Morphic is developing a family of next generation α4β7 small molecule inhibitors with enhanced attributes using the MInT Platform. These candidates have distinct chemical properties from our first-generation inhibitors with differentiated selectivity, potency, and pharmacokinetic profiles. Morphic’s next generation α4β7 inhibitors are currently in preclinical development.