Opportunities

If you are interested in a career at Morphic please submit your CV below.

Description and Key Responsibilities

We are seeking an experienced, creative and highly motivated expert with industry research experience in DMPK focused on small molecule lead optimization for discovery research programs and preclinical drug development.  Reporting to the CSO, a well-qualified individual has proven abilities to build and lead our overall DMPK strategy including design, execution, analysis, interpretation and communication of all non-clinical and early clinical PK/ADME studies.  The role will suit an individual with a passion for science, is highly motivated, with a sense of urgency to deliver in an early stage, fast paced biotech company. The candidate must have broad capabilities across PK/ADME, PK/PD and clinical pharmacology as they will work with and potentially lead cross discipline teams to facilitate the successful achievement of lead optimization programs and the rapid and efficient progression of drug candidates in preclinical development.

Qualifications

The candidate should have a PhD or equivalent degree in pharmacokinetics (PK), drug metabolism or a related field, with a minimum of 10 years of pharmaceutical industry experience.

A strong background and knowledge in ADME and PK/PD as applied in small molecule lead optimization, with a deep understanding of the free drug hypothesis, and potentially have experience with multiple drug modalities.

Exceptional knowledge of metabolic routes of biotransformation, metabolite identification and the chemistry of drug metabolism are required.

Demonstrated technical knowledge in multiple DMPK areas through a strong publication record demonstrating an in depth understanding of the experimental DMPK methodologies and approaches, in vitro and in vivo, utilized in chemical lead optimization (LO).

An experienced DMPK scientific leader that is highly motivated with exceptional interpersonal, written and oral communication skills.

An ability to work with multiple disciplines in drug discovery and provide exceptional guidance to medicinal chemists in the LO process.

Critical ability to identify and support relevant external collaborations.

Experience with multiple INDs, BLAs and/or NDAs is required with an ability to provide regulatory guidance and feedback.

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives.  In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

Description and Responsibilities

Morphic Therapeutic is currently seeking a highly-motivated individual with extensive drug discovery leadership experience and strong scientific background to lead the fibrosis discovery research. The candidate will design and implement program strategies for anti-fibrotic therapies, and work with a cross-functional team to identify high-quality drug developmental candidates. This candidate will oversee a group of PhD and non-PhD scientists providing scientific and technical leadership to improve disease understanding and drive novel drug discovery in the fibrotic disease area. The candidate should be a fast-learner and highly results-oriented, possess critical and strategic thinking ability, have excellent communication skills, and collaborate effectively with both internal team and external collaborators.

Qualifications

Education:

Ph.D. or MD degree in life sciences with a minimum of 10 years of drug discovery experience in biotech or pharmaceutical industry

Requirements:

  • Demonstrated track record in the drug discovery programs and delivery of drug candidates into Development, preferably through IND
  • Extensive discovery project leadership experience (target validation, lead identification and optimization) with the ability to define strategy and work effectively across multiple teams
  • Broad knowledge of drug discovery processes (including screening strategies, pharmacology, pharmacokinetics, medicinal chemistry or biotherapeutics, pharmaceutics/CMC, toxicology) and industry best-practices
  • Experience of fibrotic diseases or related therapeutic areas (e.g. cardiometabolic diseases) with knowledge of in vitro and in vivo models utilized in the fibrosis research.
  • Exceptional managerial skills with proven ability to mentor and grow employees to promote scientific excellence, and to lead by example to encourage collaboration across teams to achieve the company objectives.
  • Proven track record of fostering creativity, productivity, execution with a sense of urgency, teamwork, accountability, and cross-functional collaboration.
  • Experience in establishing and managing external collaborations
  • Strong verbal and written communication skills

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives.  In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

Description and Key Responsibilities

The role will suit an individual with a passion for science, is highly motivated, with a sense of urgency to deliver in an early stage, fast paced biotech company.

  • Lead a multi-disciplinary project, including direct responsibility for medicinal chemistry efforts that enable project progression
  • Develop a strategic and tactical plan for integrated chemistry projects; broadly impact the strategy of other portfolio projects and assume responsibility to advance at least one additional project
  • Utilize modern drug design techniques to design inhibitors based on structural insights, in silico modeling and physiochemical properties
  • Work closely with Schrödinger scientists to utilize structure based drug design and computational predictions to advance projects quickly and efficiently
  • Work within a multi-disciplinary team and collaborate with multiple groups including biology, computational chemistry, pharmacokinetics and pharmacology
  • Manage at least one research associate/ entry-level PhD, and mentor junior scientists broadly. Direct a large external chemistry effort to advance projects
  • Play a key role in leading/ influencing the entire Morphic Rock scientific team’s strategy and research philosophy

Qualifications

  • Ph.D. (or equivalent) in chemistry with 8+ years of research experience
  • Track record of innovation and creative problem solving as evidenced by leading the design of multiple compounds that have entered clinical testing
  • Comprehensive understanding of applying molecular properties, DMPK concepts and pharmacodynamics responses to the discovery of high quality clinical candidates
  • Ability to apply chemical informatics and other computational tools to lead optimization
  • Experience in structure based drug design and working with computational chemists/ structural biologists
  • Ability to identify and support relevant external collaborations, and manage a large chemistry team externally
  • Exceptional communication, interpersonal, and managerial skills
  • Flexible, open minded, tactful, and inclusive. Able to motivate, guide and inspire integrated teams

Apply Now!

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