Opportunities

If you are interested in a career at Morphic please submit your CV below.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Timothy Springer, PhD, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates.  Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors.  In September 2018, Morphic Therapeutic completed an $80M Series B financing round to advance multiple programs into the clinic.  Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated.  The combination of Morphic’s deep Integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications.  Morphic’s laboratories are located in the AstraZeneca BioHub in Waltham, MA.  We are looking for a scientist that displays integrity and pride in their work.  An ideal candidate will be determined, value teamwork, and share Morphic’s compassion towards patients.

Job description

Morphic Therapeutic is seeking a highly motivated DMPK scientist (Scientist/Sr. Scientist/Principal Scientist). The successful candidate will serve as the modeling and simulation expert on project teams and evaluate DMPK and PKPD properties to enable prediction and characterization of clinical dosing regimens for drug discovery and development programs. The position will be part of a multi-disciplinary team at Morphic, working together towards transformative small molecule therapeutics for autoimmune and fibrotic diseases. A strong knowledge in quantitative PKPD or chemical engineering is required.

Responsibilities

  • Perform complex PK analysis, model development, and PK/PD modeling to evaluate translational PKPD properties of drug candidates
  • Integrate and communicate PKPD information and provide guidance to internal and external collaborators/CROs on the design and data interpretation for DMPK and PKPD studies
  • Partner closely with chemistry and biology colleagues to build compound screen and optimization strategies through mechanistic and quantitative understanding of PK and PD behaviors of drug candidates
  • Interface with development colleagues and provide translational PKPD information to help design efficient preclinical and clinical development programs

Qualifications

  • Graduate degree in Quantitative Pharmacokinetic/Pharmacodynamic modeling or Chemical Engineering for Ph.D. with 2+ years, or a M.S. with 5+ years of related experience
  • In-depth knowledge and hands-on experience in compartmental PK analysis and PKPD modeling techniques and tools such as WinNonLin/Phoenix, MetLab/Simbiology or NONMEM
  • Experience in human PK prediction methodologies including allometry, IVIVC or PBPK
  • Experience in in vitro and in vivo ADME assays and managing/collaborating with CROs is a plus
  • Strong organization, multi-tasking, interpersonal and communication skills

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies. Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates. Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors. In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic. Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated. The combination of Morphic’s deep integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications. Morphic’s laboratories are located in the AstraZeneca BioHub in Waltham, MA. We seek a highly talented and motivated scientist to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity!

Job description

Morphic Therapeutics is currently seeking a highly motivated research associate to join our newly formed and growing translational pharmacology/biomarker group. The candidate will collaborate cross-functionally with the immunology, fibrosis, and oncology groups. The candidate is expected to be able to multi-task and pay attention to detail. Strong experimental and technical research skills as well as excellent communication skills are required. Creative problem solving will be an integral part of the job. The candidate will work under direct supervision to learn core assays as well as develop innovative new assays in a team environment with plenty of growth opportunity.

Responsibilities

  • Help transform common analytical methods into clinically meaningful endpoints for patients
  • Develop and trouble shoot new and innovative assays
  • Perform ex vivo sample analysis on a wide array of technology platforms in support of lead project development
  • Gain familiarity with state of the art technologies and help determine best path to success for a given project
  • Analyze experimental results and accurately extract information from the data for presentations to peers and management on the team

Qualifications

  • Sc. degree with a minimum of 2-3 years or M.Sc. degree with a minimum of 1-2 years of industry or academic experience in pharmacology, physiology, pathology or related field.
  • Familiar with basic lab procedures including qPCR, ELISA, Western Blot, cell culture and cell-based assays
  • Fast learner with curiosity for new techniques
  • Creativity is highly valued
  • Experience in basic in vivo skills

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates.  Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors.  In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic.  Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated.  The combination of Morphic’s deep Integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications.  Morphic’s laboratories are located in the AstraZeneca BioHub in Waltham, MA.  We seek a highly talented and motivated scientist to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity!

Description

Morphic Therapeutic is currently seeking a Scientist with experience in identifying, validating, and advancing drug targets for fibrosis disorders. The individual should have knowledge of advanced principles, theories and concepts in area of expertise. The individual should be highly self-motivated, possess strong experimental and technical research skills, have strong written and oral communication skills, and be able to work productively in a collaborative and cross functional team environment within and outside of Morphic Therapeutic. Relevant areas of training include fibrosis diseases, metabolic disorders, or immunology.

Responsibilities

The candidate will be expected to design, plan, and execute experiments in the laboratory and provide scientific and strategic input into the target portfolio. The candidate will also be expected to champion and launch new initiatives and drive innovation, coordinate research activities across multiple functional areas, and manage collaborative projects. The candidate may serve as a scientific mentor to junior team members

Qualifications

Education:

PhD degree in life science with 1~3 years of industry or academia experience.

Required qualifications and skills:

  • Experience in one or more of the following areas: fibrosis disease, metabolic disorders, and immunology
  • In vitro skills including general molecular and cellular biology, cell-based assay, assay development, and ex vivo tissue analysis
  • In vivo skills including animal handling, dosing, sampling, and relevant in vivo models
  • Demonstrated ability for multi-tasking and high productivity
  • Demonstrated ability for strategic thinking and problem-solving

Preferred skills:

  • Experience in survival rodent surgery is a plus
  • Experience in program leadership is a plus

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies. Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates. Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors. In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic. Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated. The combination of Morphic’s deep Integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications. Morphic’s laboratories are located in the AstraZeneca BioHub in Waltham, MA. We seek a highly talented and motivated scientist to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity!

Job description

Morphic Therapeutic is seeking an accomplished, innovative, and motivated Protein Biochemist. The position will be part of a multi-disciplinary team at Morphic, working together towards transformative small molecule therapeutics for autoimmune and fibrotic diseases, as well as immuno-oncology. A strong track record of working with highly challenging protein targets or biologics is required.

Responsibilities

  • Construct design/expression/purification of novel integrin complexes and other challenging proteins using mammalian cells
  • Developing constructs and cell lines for biophysical and biochemical assays
  • Working with crystallographers to design experiments for structural studies
  • Production of recombinant antibodies, fusion proteins, and other biologics for in vivo studies
  • Present results (written and oral) to internal and external audiences
  • Mentoring and developing junior staff

Qualifications

  • PhD in Biochemistry, Molecular Biology, Structural Biology, or equivalent with a minimum of two years of post-graduate experience, preferably in Industry.
  • In-depth knowledge and hands-on experience in working with mammalian cell surface receptors, difficult-to-express drug targets, and protein complexes.
  • Extensive experience in mammalian construct design, recombinant protein expression, purification and characterization.
  • Hands-on experience in transient expression with mammalian cells and stable cell line development
  • Well versed in recombinant DNA techniques
  • Experience in protein crystallography and structural biology is highly desirable.
  • Experience in insect cell, yeast, and bacterial expression systems is a plus.
  • Demonstrated abilities of critical and creative thinking, as well as problem-solving
  • Proven interest in mentoring and guiding junior employees
  • Experience in managing and collaborating with CROs is a plus
  • Strong organization, interpersonal and communication skills are required.

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.Ph

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