Opportunities

If you are interested in a career at Morphic please submit your CV below.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Timothy Springer, PhD, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates.  Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors.  In September 2018, Morphic Therapeutic completed an $80M Series B financing round to advance multiple programs into the clinic.  Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated.  The combination of Morphic’s deep Integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications.  Morphic’s laboratories are located in the AstraZeneca BioHub in Waltham, MA.  We are looking for a scientist that displays integrity and pride in their work.  An ideal candidate will be determined, value teamwork, and share Morphic’s compassion towards patients.

Job description

Morphic Therapeutic is seeking a highly motivated DMPK scientist (Scientist/Sr. Scientist/Principal Scientist). The successful candidate will serve as the modeling and simulation expert on project teams and evaluate DMPK and PKPD properties to enable prediction and characterization of clinical dosing regimens for drug discovery and development programs. The position will be part of a multi-disciplinary team at Morphic, working together towards transformative small molecule therapeutics for autoimmune and fibrotic diseases. A strong knowledge in quantitative PKPD or chemical engineering is required.

Responsibilities

  • Perform complex PK analysis, model development, and PK/PD modeling to evaluate translational PKPD properties of drug candidates
  • Integrate and communicate PKPD information and provide guidance to internal and external collaborators/CROs on the design and data interpretation for DMPK and PKPD studies
  • Partner closely with chemistry and biology colleagues to build compound screen and optimization strategies through mechanistic and quantitative understanding of PK and PD behaviors of drug candidates
  • Interface with development colleagues and provide translational PKPD information to help design efficient preclinical and clinical development programs

Qualifications

  • Graduate degree in Quantitative Pharmacokinetic/Pharmacodynamic modeling or Chemical Engineering for Ph.D. with 2+ years, or a M.S. with 5+ years of related experience
  • In-depth knowledge and hands-on experience in compartmental PK analysis and PKPD modeling techniques and tools such as WinNonLin/Phoenix, MetLab/Simbiology or NONMEM
  • Experience in human PK prediction methodologies including allometry, IVIVC or PBPK
  • Experience in in vitro and in vivo ADME assays and managing/collaborating with CROs is a plus
  • Strong organization, multi-tasking, interpersonal and communication skills

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies. Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates. Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors. In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic. Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated. The combination of Morphic’s deep Integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications. Morphic’s laboratories are located in the AstraZeneca BioHub in Waltham, MA. We seek a highly talented and motivated scientist to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity!

Job description

Morphic Therapeutic is seeking an accomplished, innovative, and motivated Protein Biochemist. The position will be part of a multi-disciplinary team at Morphic, working together towards transformative small molecule therapeutics for autoimmune and fibrotic diseases, as well as immuno-oncology. A strong track record of working with highly challenging protein targets or biologics is required.

Responsibilities

  • Construct design/expression/purification of novel integrin complexes and other challenging proteins using mammalian cells
  • Developing constructs and cell lines for biophysical and biochemical assays
  • Working with crystallographers to design experiments for structural studies
  • Production of recombinant antibodies, fusion proteins, and other biologics for in vivo studies
  • Present results (written and oral) to internal and external audiences
  • Mentoring and developing junior staff

Qualifications

  • PhD in Biochemistry, Molecular Biology, Structural Biology, or equivalent with a minimum of two years of post-graduate experience, preferably in Industry.
  • In-depth knowledge and hands-on experience in working with mammalian cell surface receptors, difficult-to-express drug targets, and protein complexes.
  • Extensive experience in mammalian construct design, recombinant protein expression, purification and characterization.
  • Hands-on experience in transient expression with mammalian cells and stable cell line development
  • Well versed in recombinant DNA techniques
  • Experience in protein crystallography and structural biology is highly desirable.
  • Experience in insect cell, yeast, and bacterial expression systems is a plus.
  • Demonstrated abilities of critical and creative thinking, as well as problem-solving
  • Proven interest in mentoring and guiding junior employees
  • Experience in managing and collaborating with CROs is a plus
  • Strong organization, interpersonal and communication skills are required.

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates.  Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors.  In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic.  Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated.  The combination of Morphic’s deep Integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications.  Morphic’s laboratories are located in the AstraZeneca BioHub in Waltham, MA.  We seek a highly talented and motivated scientist to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity!

Job description

Morphic Therapeutic is seeking a skilled synthetic organic chemist to join our medicinal chemistry team.  The role will suit an individual with a passion for science, strong problem-solving skills, and a sense of urgency to deliver in an early stage, fast paced biotech company.

Responsibilities

  • Be a key driver of synthetic chemistry problem solving and strategy for multiple projects
  • Solve difficult synthetic organic chemistry challenges, both directly in lab, as well as intellectually. Design routes to key targets of interest
  • Communicate and enable external chemistry teams through these efforts with high efficiency
  • Work closely with multiple internal chemists to prioritize chemistry efforts to advance projects quickly in a collaborative manner
  • Mentor junior chemists in the lab to enhance their skills and productivity
  • Take responsibility for key Morphic equipment and tools to enhance department effectiveness
  • Participate in the design of drug-like molecules that utilize practical synthetic techniques to efficiently deliver compounds for biological testing
  • As a key member of Morphic’s scientific staff, positively influence Morphic’s overall scientific and corporate culture.

 

Qualifications

  • PhD (or equivalent) in chemistry with 0-3 years of research experience
  • Track record of innovation and creative problem solving as evidenced by completing the synthesis of complex molecules
  • Passionate about hands-on organic synthesis of small molecules with a broad knowledge of modern synthetic organic chemistry and synthetic methods including multi-step synthesis; in-depth knowledge and hands-on experience with a wide range of techniques in synthesis, purification, and spectroscopic characterization of novel compounds (NMR, LC-MS, HPLC, etc.).
  • Strong publication record in organic synthesis
  • Ability to utilize analytical tools to determine the structure of complex molecules
  • Flexible, open minded, tactful, creative and inclusive
  • Ability to guide external collaborations, in particular, external synthetic organic chemistry at CROs
  • Exceptional communication and interpersonal skills, known as an excellent member of teams working together to solve difficult scientific challenges

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates.  Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors.  In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic.  Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated.  The combination of Morphic’s deep Integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications.  Morphic’s laboratories are located in the AstraZeneca BioHub in Waltham, MA.  We seek a highly talented and motivated Research associate to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity!

Description

Morphic Therapeutic is currently seeking a Senior Research Associate with strong in vitro and in vivo skills. The candidate will work cross-functionally within the organization to contribute to the areas of fibrosis, immunology, and oncology. The candidate is expected to be multi-tasking and able to execute complex experiments with strong attention to details under daily supervision. The candidate should be highly motivated, creative and flexible, possess strong experimental skills, have excellent communication skills, and collaborate effectively in a team environment.

Responsibilities

  • Perform standard procedures in live rodent models
  • Conduct in vitro cell-based assays independently for anti-fibrotic compound evaluation
  • Develop and conduct mechanism of action studies and/or proof of concept studies for targets of interest
  • Analyze experimental results and accurately extract information from the data for presentations to peers and management

Qualifications

Education:

B.Sc. degree with a minimum of 5-7 years or M.Sc. degree with a minimum of 3-5 years of industry or academic experience in life science.

Required qualifications and skills:

  • In vivo skills including routine animal handling, dosing, and relevant in vivo assays
  • Proficient with necropsy
  • Cellular biology and cell-based assays including IF, FACS, qPCR etc.
  • Ex vivo sample processing and analysis
  • Fast learner and show curiosity in new techniques

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates.  Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors.  In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic.  Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated.  The combination of Morphic’s deep Integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications.  Morphic’s laboratories are located in the AstraZeneca BioHub in Waltham, MA.  We seek a highly talented and motivated scientist to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity!

Job description

Morphic Therapeutic is seeking a skilled medicinal chemist to join our team. The role will suit an individual with a passion for science, strong problem-solving skills, and a sense of urgency to deliver in an early stage, fast paced biotech company.

Responsibilities

  • Provide chemistry leadership for project teams
  • Utilize modern drug design techniques to design inhibitors based on structural insights, in silico modeling and physiochemical properties
  • Work closely with Schrödinger scientists to utilize structure-based drug design and computational predictions to advance projects quickly and efficiently
  • Communicate and enable external chemistry teams to solve synthetic issues in an efficient manner
  • Work closely with internal chemists to advance projects quickly in a collaborative manner
  • As a key member of Morphic’s medicinal chemistry team, positively influence Morphic’s overall scientific and corporate culture

Qualifications

  • Ph.D. (or equivalent) in chemistry with 5+ years of research experience
  • Deep understanding of synthetic and medicinal chemistry, as evidenced by a record of achievement
  • Track record of innovation and creative problem solving
  • Previous project leadership experience preferred
  • Experience in structure-based drug design and working with computational chemists/ structural biologists preferred
  • Flexible, tenacious, open minded, creative and inclusive
  • Ability to guide external synthetic organic chemistry at CROs
  • Exceptional communication and interpersonal skills, known as an excellent team member working together to solve difficult scientific challenges

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies. Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates. Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors. In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic. We recently announced a collaboration with AbbVie on a subset of our fibrosis programs. Under the terms of the agreement, AbbVie paid Morphic an upfront payment of $100 million for exclusive license options on product candidates directed at multiple targets. Moprhic retains co-development rights in liver indications. Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated. The combination of Morphic’s deep Integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications. Morphic’s laboratories are located in the AstraZeneca BioHub in Waltham, MA. We seek a highly talented and motivated scientist to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity!

Job description

Morphic Therapeutic is currently seeking an in vivo scientist/vivarium manager with excellent research skills and written and oral communication skills. The individual should be highly self-motivated and be able to work productively in a collaborative and cross functional team environment. Relevant areas of training include fibrosis, oncology, or immunological diseases.

Responsibilities

The individual will be expected to execute complex biological experiments in the laboratory, both in vitro and ex vivo, to drive discovery programs forward. The individual is expected to analyze and interpret experimental results, and prepare for presentations to peers and management. The individual will serve as the in vivo representative for IACUC/Morphic TX relationship, and oversees vivarium maintenance and in vivo activities. The individual should possess demonstrated ability for multi-tasking and high productivity to impact company portfolio. The individual should be able to coordinate in vivo research efforts and must be a team player and adaptable to many different roles within a team.

Qualifications

Education:

B.Sc. degree with a minimum of 7 years or M.Sc. degree with a minimum of 5 years of experience in biotech or pharmaceutical companies.

Required qualifications and skills:

  • Demonstrate excellent skills in laboratory procedures
  • Establish appropriate in vivo-based model systems for compound testing
  • Lead animal studies in preclinical models, including study designs, resource coordination and data analysis
  • In vivo skills including animal handling, various routes of compound administration, and survival surgery
  • Proficiency with necropsy and tissue processing
  • Ex vivo sample processing and analysis, including blood and tissue endpoint measurement
  • Ability to analyze, interpret, and present study results to project teams
  • Coordination of in vivo activities, including animal ordering, IACUC protocol approval and amendment, and compliance checks.

Preferred skills:

  • Familiarity with rodent models of fibrosis, immunology, or immune-oncology

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies. Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates. Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors. In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic. We recently announced a collaboration with AbbVie on a subset of our fibrosis programs. Under the terms of the agreement, AbbVie paid Morphic an upfront payment of $100 million for exclusive license options on product candidates directed at multiple targets. Moprhic retains co-development rights in liver indications. Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated. The combination of Morphic’s deep Integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications. Morphic’s laboratories are located in the AstraZeneca BioHub in Waltham, MA. We seek a highly talented and motivated scientist to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity!

Job description

Responsibilities

Morphic is currently seeking a highly-motivated individual with extensive drug discovery leadership experience and strong scientific background to lead the immune-oncology discovery research. The candidate will design and implement program strategies for immune-oncology therapies, and work with a cross-functional team to identify high-quality drug developmental candidates. This candidate will oversee a group of PhD and non-PhD scientists providing scientific and technical leadership to improve mechanistic understanding of targets and drive novel drug discovery in the immunology and oncology disease areas. The candidate should be a fast-learner and highly results-oriented, possess critical and strategic thinking ability, have excellent communication skills, and collaborate effectively with both internal teams and external collaborators.

Required qualifications:

  • PhD or MD degree in life sciences with a minimum of 10 years of drug discovery and research experience in academic or industry
  • Must have strong immunology background and deep experience in immune-oncology with knowledge of in vitro and in vivo models utilized in the immune-oncology research
  • Broad knowledge in the competitive landscape of immune-oncology
  • Experience in setting up disease area strategy
  • Demonstrated track record in target validation and drug discovery programs
  • Extensive discovery project leadership experience (target validation, lead identification and optimization) with the ability to define strategy and work effectively across multiple teams
  • Exceptional managerial skills with proven ability to mentor and grow employees to promote scientific excellence, and to lead by example to encourage collaboration across teams to achieve the company objectives.
  • Proven track record of fostering creativity, productivity, execution with a sense of urgency, teamwork, accountability, and cross-functional collaboration.
  • Experience in establishing and managing external collaborations
  • Strong verbal and written communication skills

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies. Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates. Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors. In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic. We recently announced a collaboration with AbbVie on a subset of our fibrosis programs. Under the terms of the agreement, AbbVie paid Morphic an upfront payment of $100 million for exclusive license options on product candidates directed at multiple targets. Morphic retains co-development rights in liver indications. Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated. The combination of Morphic’s deep integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications. Morphic’s laboratories are located in the AstraZeneca BioHub in Waltham, MA. We are looking for a scientist that displays integrity and pride in their work. An ideal candidate will be determined, value teamwork, and share Morphic’s compassion towards patients.

Job description

Morphic Therapeutic is seeking a highly motivated scientist to join the Screening Group. The new hire will be responsible for developing novel assays that will need to be robust enough to be used in high throughput screening. We are looking for someone with industry experience in assay development and screening so that the person can immediately and independently develop these assays.

Responsibilities

  • Design and implement biochemical and cell-based assays to characterize compound activity
  • Perform multicolor flow cytometry, high content imaging, and cell reporter assays
  • Perform fluorescence-based protein binding assays, ELISA, and protein analysis
  • Actively contribute to group discussions on data analysis and project strategies

Qualifications & Required Skills

  • Ph.D. degree with 3 years industry experience in biological assay development and drug discovery
  • Background in cell biology and biochemistry
  • Knowledgeable on new techniques and ability to develop innovative assays
  • Enthusiastic to contribute through laboratory work
  • Highly motivated with the ability to motivate other

Preferred Skills:

  • Experience in assay development for high throughput screening
  • Experience in characterizing protein-protein interactions and elucidating compound mode of action
  • Knowledgeable or hands-on experience working on integrins

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

Apply Now!