Opportunities

If you are interested in a career at Morphic please submit your CV below.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates.  Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors.  In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic.  Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated.  The combination of Morphic’s deep Integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications.  Morphic’s laboratories are located in the AstraZeneca BioHub in Waltham, MA.  We seek a highly talented and motivated scientist to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity!

Job description

Morphic Therapeutic is seeking a skilled medicinal chemist to join our team. The role will suit an individual with a passion for science, strong problem-solving skills, and a sense of urgency to deliver in an early stage, fast paced biotech company.

Responsibilities

  • Provide chemistry leadership for project teams
  • Utilize modern drug design techniques to design inhibitors based on structural insights, in silico modeling and physiochemical properties
  • Work closely with Schrödinger scientists to utilize structure-based drug design and computational predictions to advance projects quickly and efficiently
  • Communicate and enable external chemistry teams to solve synthetic issues in an efficient manner
  • Work closely with internal chemists to advance projects quickly in a collaborative manner
  • As a key member of Morphic’s medicinal chemistry team, positively influence Morphic’s overall scientific and corporate culture

Qualifications

  • Ph.D. (or equivalent) in chemistry with 5+ years of research experience
  • Deep understanding of synthetic and medicinal chemistry, as evidenced by a record of achievement
  • Track record of innovation and creative problem solving
  • Previous project leadership experience preferred
  • Experience in structure-based drug design and working with computational chemists/ structural biologists preferred
  • Flexible, tenacious, open minded, creative and inclusive
  • Ability to guide external synthetic organic chemistry at CROs
  • Exceptional communication and interpersonal skills, known as an excellent team member working together to solve difficult scientific challenges

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies. Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates. Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors. In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic. We recently announced a collaboration with AbbVie on a subset of our fibrosis programs. Under the terms of the agreement, AbbVie paid Morphic an upfront payment of $100 million for exclusive license options on product candidates directed at multiple targets. Moprhic retains co-development rights in liver indications. Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated. The combination of Morphic’s deep Integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications. Morphic’s laboratories are located in the AstraZeneca BioHub in Waltham, MA. We seek a highly talented and motivated scientist to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity!

Job description

Responsibilities

Morphic is currently seeking a highly-motivated individual with extensive drug discovery leadership experience and strong scientific background to lead the immune-oncology discovery research. The candidate will design and implement program strategies for immune-oncology therapies, and work with a cross-functional team to identify high-quality drug developmental candidates. This candidate will oversee a group of PhD and non-PhD scientists providing scientific and technical leadership to improve mechanistic understanding of targets and drive novel drug discovery in the immunology and oncology disease areas. The candidate should be a fast-learner and highly results-oriented, possess critical and strategic thinking ability, have excellent communication skills, and collaborate effectively with both internal teams and external collaborators.

Required qualifications:

  • PhD or MD degree in life sciences with a minimum of 10 years of drug discovery and research experience in academic or industry
  • Must have strong immunology background and deep experience in immune-oncology with knowledge of in vitro and in vivo models utilized in the immune-oncology research
  • Broad knowledge in the competitive landscape of immune-oncology
  • Experience in setting up disease area strategy
  • Demonstrated track record in target validation and drug discovery programs
  • Extensive discovery project leadership experience (target validation, lead identification and optimization) with the ability to define strategy and work effectively across multiple teams
  • Exceptional managerial skills with proven ability to mentor and grow employees to promote scientific excellence, and to lead by example to encourage collaboration across teams to achieve the company objectives.
  • Proven track record of fostering creativity, productivity, execution with a sense of urgency, teamwork, accountability, and cross-functional collaboration.
  • Experience in establishing and managing external collaborations
  • Strong verbal and written communication skills

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic Inc. is a biotechnology company developing a new generation of oral integrin therapies. Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has built a robust pipeline of integrin inhibitors for the treatment of fibrosis, autoimmune disease and cancer. Morphic was created in 2015, raised $51.5M Series A in 2016 and $80M Series B in 2018 to bring multiple programs into the clinic. Recently, we partnered with AbbVie on a subset of our fibrosis programs. Under the terms of the agreement, AbbVie paid Morphic an upfront payment of $100 million for exclusive license options on product candidates directed at multiple targets. Moprhic retains co-development rights in liver indications. Morphic is located in the AstraZeneca BioHub in Waltham, MA. We seek a highly talented and motivated scientist to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Job description

Morphic is searching for a creative, resourceful and dynamic individual to join our growing company to lead the Analytical Development function within CMC. The Associate Director/Director will provide analytical expertise and leadership in the development of drug substance and drug product from early phase through commercialization. This position will oversee analytical development activities at CDMOs, ensure quality and timeliness of work, author and review relevant sections of INDs and IMPDs. The Associate Director/Director will lead and/or contribute to various departmental and cross-functional teams as assigned.

Responsibilities

  • Serve as the analytical development technical lead for drug substance and drug product
  • Responsible for leading the development, validation, implementation, technology transfer of analytical methods to support all stages of drug development
  • Provide leadership, direction and analytical support for investigations and troubleshooting analytical issues
  • Design stability studies to support shelf life and storage statements for drug substance and drug product
  • Propose and justify specifications for drug substance and drug product
  • Coordinate with QA and Regulatory as well as Clinical and Toxicology regarding safety-related questions on APIs, components of APIs, formulations and materials used in processing
  • Review and approve analytical data, technical protocols/reports and analytical methods in support of regulatory CMC filings
  • Author and review relevant sections of INDs, IMPDs and prepare responses to CMC questions from regulatory agencies
  • Build collaborative and long-term relationships with CDMO partners
  • Assist in the development and communication of department goals and strategy
Minimum Requirements
  • PhD in chemistry or analytical chemistry with 10 plus years of relevant experience in analytical development within the pharmaceutical industry
  • Proven experience in developing and implementing analytical methods used to support product development, characterization and release
  • Proven track record in managing analytical/QC activities in all stages of drug development
  • Knowledge and understanding of current ICH guidelines, relevant FDA guideliens and cGMPs
  • Effective verbal and written communication skills

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies. Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates. Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors. In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic. We recently announced a collaboration with AbbVie on a subset of our fibrosis programs. Under the terms of the agreement, AbbVie paid Morphic an upfront payment of $100 million for exclusive license options on product candidates directed at multiple targets. Morphic retains co-development rights in liver indications. Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated. The combination of Morphic’s deep integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications. Morphic’s laboratories are located in the AstraZeneca BioHub in Waltham, MA. We are looking for a scientist that displays integrity and pride in their work. An ideal candidate will be determined, value teamwork, and share Morphic’s compassion towards patients.

Job description

Morphic Therapeutic is seeking a skilled synthetic organic chemist to join our medicinal chemistry team. This position will be primarily lab based with a strong focus on chemistry problem solving for the synthesis of key analogs. Additional responsibilities may include route design and trouble-shooting in collaboration with one or more ore of our globally placed chemistry CROs. The role will suit an individual with a passion for science, strong problem-solving skills, and a sense of urgency to deliver in an early stage, fast paced biotech company.

Responsibilities

  • Be a key driver of synthetic chemistry problem solving and strategy for multiple projects
  • Solve difficult synthetic organic chemistry challenges, both directly in lab, as well as intellectually
  • Design routes to key targets of interest
  • Communicate and enable external chemistry teams through these efforts with high efficiency
  • Work closely with multiple internal chemists to prioritize chemistry efforts to advance projects quickly in a collaborative manner
  • Mentor junior chemists in the lab to enhance their skills and productivity
  • Take responsibility for key Morphic equipment and tools to enhance department effectiveness
  • Participate in the design of drug-like molecules that utilize practical synthetic techniques to efficiently deliver compounds for biological testing
  • As a key member of Morphic’s scientific staff, positively influence Morphic’s overall scientific and corporate culture.

Qualifications

  • Ph.D. (or equivalent) in chemistry with 0-3 years of research experience
  • Track record of innovation and creative problem solving as evidenced by completing the synthesis of complex molecules
  • Passionate about hands-on organic synthesis of small molecules with a broad knowledge of modern synthetic organic chemistry and synthetic methods including multi-step synthesis; in-depth knowledge and hands-on experience with a wide range of techniques in synthesis, purification, and spectroscopic characterization of novel compounds (NMR, LC-MS, HPLC, etc.).
  • Strong publication record in organic synthesis
  • Ability to utilize analytical tools to determine the structure of complex molecules
  • Flexible, open minded, tactful, creative and inclusive
  • Ability to guide external collaborations, in particular, external synthetic organic chemistry at CROs
  • Exceptional communication and interpersonal skills, known as an excellent member of teams working together to solve difficult scientific challenges

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic Inc. is a biotechnology company developing a new generation of oral integrin therapies. Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has built a robust pipeline of integrin inhibitors for the treatment of fibrosis, autoimmune disease and cancer. Morphic was created in 2015, raised $51.5M Series A in 2016 and $80M Series B in 2018 to bring multiple programs into the clinic. Recently, we partnered with AbbVie on a subset of our fibrosis programs. Under the terms of the agreement, AbbVie paid Morphic an upfront payment of $100 million for exclusive license options on product candidates directed at multiple targets. Moprhic retains co-development rights in liver indications. Morphic is located in the AstraZeneca BioHub in Waltham, MA. We seek a highly talented and motivated scientist to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Job Description:

The Principal Scientist, Translational Sciences will provide expertise in translational bioassay technologies and be responsible for development, qualification and implementation of biomarker assays in the clinic. The successful candidate will be a skilled team player who is able to work in a highly collaborative function, working at the interface between research and development. Candidates should have experience in assay development, transfer and monitoring of protein-based assays and should have a willingness to serve as both a strategic and hands-on technical leader within the team.

Responsibilities:

  • Display Morphic core values of craftsmanship, tenacity, teamwork, integrity, and compassion
  • Develop biomarker assays that are qualified fit-for-purpose for the clinical objectives of the program and transfer them to appropriate clinical test facilities
  • Antibody selection and validation
  • Perform initial method development to facilitate outsourcing
  • Maintain instrumentation and monitor for new technology
  • Help to maintain organized sample library/repository of relevant samples for various diseases
  • Collaborate with academic labs
  • Preparation of protocols, reports and regulatory summaries
  • Contribute to public presentations and publications

Qualifications:

  • PhD or equivalent with 12+ years relevant experience in field related to translational research
  • Flexible, collaborative and able to thrive in a fast-paced biotech environment
  • Direct experience in outsourcing and validation of biomarker assays and clinical protocol and study report preparation required
  • Experience in one or more of the following therapeutic areas: inflammation, liver disease, fibrosis, or oncology
  • Awareness of regulatory requirements and experience working central labs and CLIA certified labs
  • Sophisticated technical understanding across broad protein biomarker assays including flow cytometry, ELISA, MSD and IHC
  • Established track record of scientific excellence including publications and presentations at conferences

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic Inc. is a biotechnology company developing a new generation of oral integrin therapies. Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has built a robust pipeline of integrin inhibitors for the treatment of fibrosis, autoimmune disease and cancer. Morphic was created in 2015, raised $51.5M Series A in 2016 and $80M Series B in 2018 to bring multiple programs into the clinic. Recently, we partnered with AbbVie on a subset of our fibrosis programs. Under the terms of the agreement, AbbVie paid Morphic an upfront payment of $100 million for exclusive license options on product candidates directed at multiple targets. Moprhic retains co-development rights in liver indications. Morphic is located in the AstraZeneca BioHub in Waltham, MA. We seek a highly talented and motivated scientist to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Job description

Morphic Therapeutic is seeking a highly motivated Research Associate/Sr. Research Associate in Biochemistry and Structural Biology. The successful candidate will be responsible for expressing and purifying proteins of the Integrin family for use in downstream applications such as assays, structural biology, and biophysical characterization. The position will be part of a multi-disciplinary team at Morphic, working together towards transformative small molecule therapeutics for autoimmune and fibrotic diseases. A strong knowledge of biochemistry is required, lab experience in the areas of tissue culture and protein purification being preferred.

Responsibilities

  • Design and execute experiments to support research activities and project goals
  • Responsible for generating and characterizing high quality protein samples for compound activity profiling and protein crystallography
  • Maintain mammalian tissue cultures and laboratory equipment
  • Work within a multi-functional team and collaborate with multiple groups including Biology, Chemistry, and Pharmacology

Qualifications

  • BS/MS in biochemistry/biophysics/molecular cell biology or related discipline, with 2+ years of research experience.
  • Experience in protein expression and purification
  • Experience with AKTA chromatography systems, SDS-PAGE, and western blot.
  • Knowledge in basic tissue culture techniques is a plus.
  • Knowledge in X-ray crystallography and structural biology is a plus.
  • Must demonstrate a good understanding of scientific principles, experimental design, and proper laboratory techniques
  • Excellent communication, interpersonal, and organizational skills

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies. Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates. Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors. In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic. We recently announced a collaboration with AbbVie on a subset of our fibrosis programs. Under the terms of the agreement, AbbVie paid Morphic an upfront payment of $100 million for exclusive license options on product candidates directed at multiple targets. Morphic retains co-development rights in liver indications. Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated. The combination of Morphic’s deep integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications. Morphic’s laboratories are located in the AstraZeneca BioHub in Waltham, MA. We are looking for a scientist that displays integrity and pride in their work. An ideal candidate will be determined, value teamwork, and share Morphic’s compassion towards patients.

Job description

Morphic Therapeutic is seeking a highly motivated DMPK scientist (Sr. Scientist to Principle Scientist depending on qualification). The successful candidate will serve as the DMPK expert on project teams to evaluate underlying ADME mechanisms driving PK properties and to enable small molecule candidate optimization and prediction of clinical dosing regimens. The position will be part of a multi-disciplinary team at Morphic, working together towards transformative small molecule therapeutics for autoimmune and fibrotic diseases. A strong knowledge in drug transporter sciences and enzymology is required.

Responsibilities

  • Design and supervise CROs for routine and mechanistic PK and ADME studies that enable compound optimization and decision making
  • Integrate PK and PKPD information and provide guidance to internal and external collaborators on the design and data interpretation for PK and PKPD studies
  • Partner closely with chemistry and biology colleagues to build compound screen and optimization strategies through mechanistic and quantitative understanding of PK and PD properties of drug candidates
  • Interface with development colleagues and lead the preparation of PK, ADME, and drug interaction data package for regulatory filings

Qualifications

  • Ph.D. in Drug Metabolism, Pharmacokinetics, Pharmaceutics or other relevant fields with >5 years of experience in the biopharmaceutical industry
  • Strong knowledge of drug transporters, ADME concepts, and bioanalytical principles is required
  • Experience in human PK prediction methodologies including allometry, IVIVC or PBPK
  • Experience in regulatory filing, in vitro and in vivo ADME assays and managing/collaborating with CROs
  • Strong organization, multi-tasking, interpersonal and communication skills

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies. Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates. Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors. In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic. We recently announced a collaboration with AbbVie on a subset of our fibrosis programs. Under the terms of the agreement, AbbVie paid Morphic an upfront payment of $100 million for exclusive license options on product candidates directed at multiple targets. Morphic retains co-development rights in liver indications. Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated. The combination of Morphic’s deep integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications. Morphic’s laboratories are located in the AstraZeneca BioHub in Waltham, MA. We are looking for a scientist that displays integrity and pride in their work. An ideal candidate will be determined, value teamwork, and share Morphic’s compassion towards patients.

Job description

Morphic Therapeutic is seeking an accomplished, innovative, and motivated Protein Scientist/Engineer. The position will be part of world-class research team at Morphic, working together towards transformative therapeutics for autoimmune, fibrotic diseases, and immuno-oncology. The successful candidate will be responsible for creating novel biologics against disease targets using state-of-the-art yeast libraries.

Responsibilities

  • Working with a strategic academic partner to establish a yeast display platform
  • Identifying and engineering reagents for target identification and validation
  • Designing selection strategies and co-developing functional assays
  • Biophysical and biochemical characterizations of antibody-antigen interaction
  • Production of antibody for in vivo and in vitro studies
  • Present results (written and oral) to internal and external audiences
  • Mentoring and developing junior staff

Qualifications

  • Ph.D. in Biochemistry, Molecular Biology, Structural Biology, or Bioengineering with a minimum of two years of post-graduate research experience.
  • 2+ years of hands-on experience in yeast display and/or phage display, and protein engineering is required.
  • In-depth knowledge of display technologies and libraries is required.
  • Experience in mammalian protein expression, purification and characterization is highly desirable.
  • Experience in antibody affinity maturation and other display technologies is a plus.
  • Highly-skilled in recombinant DNA techniques
  • Knowledge in protein crystallography, cryo-EM, and structural biology is highly desirable.
  • Demonstrated abilities of critical and creative thinking
  • Strong problem-solving track record
  • Proven interest in mentoring and guiding junior employees
  • Experience in managing and collaborating with CROs is a plus
  • Strong organization, interpersonal and communication skills are required.

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

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