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About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Dr. Timothy A. Springer, Morphic has developed an exclusive MInT platform that facilitates the rapid discovery of clinical candidates.  Morphic was created in 2015 and raised $51.5M in 2016 from top tier investors.  In 2018, Morphic Therapeutic completed an $80 million Series B financing round and formed a collaboration with Abbvie Inc. focused on the exploration of TGF-β biology in fibrotic diseases. In 2019 Morphic formed a collaboration with Janssen Biotech, a Johnson and Johnson company to explore the potential of integrin inhibitors and activators in multiple diseases. On Jun. 26, 2019 Morphic announced the pricing of its upsized initial public offering of 6,000,000 shares of its common stock at a price to the public of $15.00 per share. The shares are trading on The Nasdaq Global Market under the symbol “MORF.”

Currently, we are advancing both partnered and fully-owned oral integrin therapeutic candidates into the clinic.  Integrin dysregulation is involved in multiple diseases that span, including inflammation, fibrosis, vascular diseases, and cancer. Our immediate focus is on the areas where the clinical activity of antibody inhibitors of integrins is precedented, thus enabling a rapid path to clinical proof-of-concept.

The Morphic Therapeutic office is located in the AstraZeneca BioHub in Waltham, MA.  We are seeking a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Job description

The associate director of clinical research science will design, implement, and evaluate clinical trials throughout the clinical development process. He or she will ensure that the quality and the reliability of the information are maintained and that the clinical research is conducted in a safe and secure work environment that adheres to internal standard operating procedures and numerous safety guidelines, including all Good Clinical Practice guidelines. The clinical research scientist will work closely with the Acting Chief Medical Officer and will coordinate with the other members of the cross-functional project teams. He will liaise with top clinical management, vendors, and external affiliated clinical investigators. She/he will report to the Chief Development Officer.

Responsibilities

  • Review company-generated scientific data and the scientific literature to develop knowledge of the company’s drug development programs. Communicate this information to affiliated clinical investigators.
  • Develop and review clinical study protocols and amendments, particularly including first-in-human, phase 1 SAD/MAD studies and specialized clinical pharmacology studies and phase 2 clinical trials.
  • Investigate and perform due diligence on novel methods and approaches for monitoring safety and assessing efficacy in clinical trials. Monitor for safety signals in clinical trials and immediately report up the chain to the CMO and pharmacovigilance function in the company.
  • Establish close working relationships with clinical research vendors to establish efficient processes for conduct of clinical research and monitor progress of studies to ensure quality data and on time execution.
  • Deliver reports and presentations on the progress and the findings of the clinical research programs.
  • Provide senior management with regular updates on the progress of the clinical research, including the generation of dashboards to monitor progress of clinical trials.
  • Support Clinical Operations in identifying vendors, preparing requests for proposals, and evaluating suitability of vendors for conducting clinical trials, including clinical CROs and ancillary support vendors.
  • Support Quality Assurance in the development, review, and approval of clinical SOPs
  • Act as a key scientific resource, providing knowledge and expertise to cross-functional project teams

Qualifications

  • Advanced degree in life sciences including Ph.D., PharmD, MD, or equivalent.
  • 10+ years relevant experience in pharma or biotech companies.
  • Formal training on ICH, GCP, and other relevant regulatory guidelines is desirable.
  • Strong scientific writing and editing skills related to clinical trial protocols and reports.
  • Strong communication and interpersonal skills
  • Ability to interact with clinical investigators and other medical experts
  • Ability to read, understand and communicate clinical information
  • Superior attention to detail, coordination, organization and collaboration, time management presentation skills, both written and oral
  • Ability to communicate complex information to internal personnel and external stakeholders

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives.  In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

Click Here to Apply Now!

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Dr. Timothy A. Springer, Morphic has developed an exclusive MInT platform that facilitates the rapid discovery of clinical candidates.  Morphic was created in 2015 and raised $51.5M in 2016 from top tier investors.  In 2018, Morphic Therapeutic completed an $80 million Series B financing round and formed a collaboration with Abbvie Inc. focused on the exploration of TGF-β biology in fibrotic diseases. In 2019 Morphic formed a collaboration with Janssen Biotech, a Johnson and Johnson company to explore the potential of integrin inhibitors and activators in multiple diseases. On Jun. 26, 2019 Morphic announced the pricing of its upsized initial public offering of 6,000,000 shares of its common stock at a price to the public of $15.00 per share. The shares are trading on The Nasdaq Global Market under the symbol “MORF.”

Currently, we are advancing both partnered and fully-owned oral integrin therapeutic candidates into the clinic.  Integrin dysregulation is involved in multiple diseases that span, including inflammation, fibrosis, vascular diseases, and cancer. Our immediate focus is on the areas where the clinical activity of antibody inhibitors of integrins is precedented, thus enabling a rapid path to clinical proof-of-concept.

The Morphic Therapeutic office is located in the AstraZeneca BioHub in Waltham, MA.  We are seeking a highly motivated and experienced Clinical Pharmacologist to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

 

Job Description:

The Director, Translational Sciences will provide expertise in translational bioassay technologies and be responsible for development, qualification and implementation of biomarker assays in the clinic. The successful candidate will be a skilled team player who is able to work in a highly collaborative function, working at the interface between research and development. Candidates should have experience in assay development, transfer and monitoring of protein-based assays and should have a willingness to serve as both a strategic and hands-on technical leader within the team.

 

Responsibilities:

  • Display Morphic core values of craftsmanship, tenacity, teamwork, integrity, and compassion
  • Develop biomarker assays that are qualified fit-for-purpose for the clinical objectives of the program and transfer them to appropriate clinical test facilities
  • Antibody reagent selection and validation
  • Perform initial method development to facilitate outsourcing
  • Maintain instrumentation and monitor for new technology
  • Help to maintain organized sample library/repository of relevant samples for various diseases
  • Collaborate with academic labs
  • Preparation of protocols, reports and regulatory summaries
  • Contribute to public presentations and publications

Qualifications:

  • PhD or equivalent with 10+ years relevant experience in field related to translational research
  • Flexible, collaborative and able to thrive in a fast-paced biotech environment
  • Sophisticated technical understanding of ‘omics technology
    • Proteomic assays including flow cytometry, ELISA, MSD and IHC technical experience
    • Transcriptomic assays including RNASeq, qPCR and Nanostring
  • Direct experience in outsourcing and validation of biomarker assays and clinical protocol and study report preparation
  • Experience in one inflammation or fibrosis therapeutic area preferred
  • Awareness of regulatory requirements and experience working with central labs and CLIA certified labs
  • Established track record of scientific excellence including publications and presentations at conferences

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives.  In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

Click Here to Apply Now!

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Dr. Timothy A. Springer, Morphic has developed an exclusive MInT platform that facilitates the rapid discovery of clinical candidates.  Morphic was created in 2015 and raised $51.5M in 2016 from top tier investors.  In 2018, Morphic Therapeutic completed an $80 million Series B financing round and formed a collaboration with Abbvie Inc. focused on the exploration of TGF-β biology in fibrotic diseases. In 2019 Morphic formed a collaboration with Janssen Biotech, a Johnson and Johnson company to explore the potential of integrin inhibitors and activators in multiple diseases. On Jun. 26, 2019 Morphic announced the pricing of its upsized initial public offering of 6,000,000 shares of its common stock at a price to the public of $15.00 per share. The shares are trading on The Nasdaq Global Market under the symbol “MORF.”

Currently, we are advancing both partnered and fully-owned oral integrin therapeutic candidates into the clinic.  Integrin dysregulation is involved in multiple diseases that span, including inflammation, fibrosis, vascular diseases, and cancer. Our immediate focus is on the areas where the clinical activity of antibody inhibitors of integrins is precedented, thus enabling a rapid path to clinical proof-of-concept.

The Morphic Therapeutic office is located in the AstraZeneca BioHub in Waltham, MA.  We are seeking a highly motivated and experienced Clinical Pharmacologist to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Job Description:

PRINCIPAL SCIENTIST (CLINICAL ASSAY TRANSFER) JOB DESCRIPTION

The Translational Sciences group at Morphic Therapeutic seeks a motivated clinical assay transfer scientist. This team member will work with the Translational Sciences team to help develop bioanalytical methods to measure markers in clinical trial samples and lead the transfer to CROs and other partners. A demonstrated ability to support clinical trial execution, synthesize scientific data and communicate key findings cross-functionally is required. This team member will also be asked to perform other duties as required to support Morphic’s pipeline development.

Responsibilities:

  • Display Morphic core values of craftsmanship, tenacity, teamwork, integrity, and compassion
  • Contribute to the development and validation of bioanalytical methods to support preclinical and clinical development of novel integrin targeted therapeutic candidates.
  • Identify and establish agreements with contract research organizations (CROs) and support the transfer of novel bioanalytical methods
  • Communicate and coordinate with clinical sites, CROs, and central labs to ensure efficient sample and data logistics
  • Work with internal development team and external partners to write, review, and edit technical documents and develop appropriate instructional materials for assay transfers
  • Contribute to internal technology evaluation, development, qualification, and execution of innovative assays for clinical sample monitoring
  • Contribute to translational science programs, and delivery of scientific discoveries that impact decision-making at team meetings
  • Contribute to company-wide and external scientific discussions and engagement with key opinion leaders in the field
  • Work with Clinical Operations and central labs to qualify data acquisition and aid in interpretation of analyses of clinical trial data
  • Support the preparation of data packages for publication, presentation and/or submission to regulatory agencies
  • Being a key player of a highly skilled translational team that shares a common goal of delivering the optimal path forward for clinical development

Qualifications:

  • PhD or equivalent in a relevant biological discipline and at least 7 years of relevant pharmaceutical industry experience
  • Relevant experience in bioanalytical assay development, qualification and validation requirements to comply with current regulatory standards
  • Experience with relevant diagnostic technologies with an emphasis on multi-color flow cytometry, multiplexed immunoassays (e.g. ELISA, MSD, Luminex), molecular biological assays
  • Proficient in relevant analytical methodology, emerging new technologies, troubleshooting and problem solving
  • Experience in CRO management and oversight for bioanalytical assay development, validation and sample analysis.
  • Working knowledge of Good Laboratory Practices (GLP)
  • Experience in inflammation preferable
  • Detail-oriented, self-motivated, and independent
  • Strong oral and written communication skills.
  • The ability and desire to work in a challenging dynamic environment under tight deadlines is required.

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives.  In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

Click Here to Apply Now!

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Dr. Timothy A. Springer, Morphic has developed an exclusive MInT platform that facilitates the rapid discovery of clinical candidates.  Morphic was created in 2015 and raised $51.5M in 2016 from top tier investors.  In 2018, Morphic Therapeutic completed an $80 million Series B financing round and formed a collaboration with Abbvie Inc. focused on the exploration of TGF-β biology in fibrotic diseases. In 2019 Morphic formed a collaboration with Janssen Biotech, a Johnson and Johnson company to explore the potential of integrin inhibitors and activators in multiple diseases. On Jun. 26, 2019 Morphic announced the pricing of its upsized initial public offering of 6,000,000 shares of its common stock at a price to the public of $15.00 per share. The shares are trading on The Nasdaq Global Market under the symbol “MORF.”

Currently, we are advancing both partnered and fully-owned oral integrin therapeutic candidates into the clinic.  Integrin dysregulation is involved in multiple diseases that span, including inflammation, fibrosis, vascular diseases, and cancer. Our immediate focus is on the areas where the clinical activity of antibody inhibitors of integrins is precedented, thus enabling a rapid path to clinical proof-of-concept.

The Morphic Therapeutic office is located in the AstraZeneca BioHub in Waltham, MA.  We are seeking a highly motivated and experienced Clinical Pharmacologist to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Job Description:

The Translational Sciences group at Morphic Therapeutic seeks a motivated scientist to conduct research to support the advancement of a portfolio of small molecule inhibitors into clinical trials in targeted indications and patient populations. This team member will help identify predictive biomarkers and pharmacodynamic biomarkers to monitor target engagement. The position requires expertise in flow cytometry, familiarity with integrin-targeted diseases, and a passion to contribute to high quality scientific research to drive programs into the clinic. We are seeking a highly motivated, independent, and skilled candidate who will be responsible for planning, execution, interpretation and presentation of data to drive translational programs.

Responsibilities:

  • Display Morphic core values of craftsmanship, tenacity, teamwork, integrity, and compassion
  • Contribute to translational science programs, and delivery of scientific discoveries that impact decision-making at team meetings
  • Design and perform complex integrin-focused experiments to support hypotheses around the biological functions and molecular mechanisms of targets
  • Identify/validate biological contexts that create a dependency on a given drug target to aid indication prioritization for clinical development. This entails both performing and guiding internal efforts, as well as external efforts with CROs or collaborators.
  • Use genomic, epigenomic, and/or transcriptomic data to generate novel biomarker hypotheses and identify novel biomarkers
  • Identify biomarker assays that assess drug pharmacodynamics and translate into protocols ready for bionalytical testing in the clinic
  • Preparation of reports and presentation of data to the team
  • Being a key player of a highly skilled translational team that shares a common goal of delivering the optimal path forward for clinical development

  Qualifications:

  • PhD in molecular or cellular biological sciences and a minimum of 3 years of industry/post doctoral experience
  • Broad knowledge and laboratory research experience in multi-color flow cytometry, immunoassays (e.g. ELISA, MSD), molecular biological assays
  • Experience handling human and animal blood and isolating blood components
  • Experience working with CROs and external collaborators for clinical assay development, implementation and execution preferred
  • Experience in inflammation preferable
  • Detail-oriented, self-motivated, and independent
  • Strong oral and written communication skills.
  • The ability and desire to work in a challenging dynamic environment under tight deadlines is required.

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives.  In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

Click Here to Apply Now!

About Morphic Therapeutic
Morphic Therapeutic is a biotechnology company developing oral integrin therapies. Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Dr. Timothy A. Springer, Morphic has developed an exclusive MInT platform that facilitates the rapid discovery of clinical candidates. Morphic was created in 2015 and raised $51.5M in 2016 from top tier investors. In 2018, Morphic Therapeutic completed an $80 million Series B financing round and formed a collaboration with Abbvie Inc. focused on the exploration of TGF-β biology in fibrotic diseases. In 2019 Morphic formed a collaboration with Janssen Biotech, a Johnson and Johnson company to explore the potential of integrin inhibitors and activators in multiple diseases. On Jun. 26, 2019 Morphic announced the pricing of its upsized initial public offering of 6,000,000 shares of its common stock at a price to the public of $15.00 per share. The shares are trading on The Nasdaq Global Market under the symbol “MORF.”
Currently, we are advancing both partnered and fully-owned oral integrin therapeutic candidates into the clinic with an anticipated first IND filing as early as the end of the year. Integrin dysregulation is involved in multiple diseases that span, including inflammation, fibrosis, vascular diseases, and cancer. Our immediate focus is on the areas where the clinical activity of antibody inhibitors of integrins is precedented, thus enabling a rapid path to clinical proof-of-concept.
The Morphic Therapeutic office is located in the AstraZeneca BioHub in Waltham, MA. We are seeking a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Job description
The Director of Clinical Operations will work closely with Chief Medical Officer to ensure successful execution of clinical trials conducted by Morphic Therapeutic. The successful candidate will initiate and manage clinical studies, oversee contract research organizations (CROs) and vendors, design and work to support clinical operations initiatives. She or he will ensure that the clinical research is conducted in a safe and secure work environment that adheres to internal standard operating procedures and applicable safety guidelines, including all Good Clinical Practice guidelines. The incumbent will work collaboratively with all development teams to guide their clinical operations activities and collaborate with key members of Discovery and Development organizations. She or he will report to the Chief Medical Officer (CMO).

Responsibilities
• Identifies clinical vendors, prepares requests for proposals, and evaluates suitability of vendors for conducting clinical trials, including clinical CROs and ancillary support vendors.
• Manages study initiation, protocol execution, selection and oversight of clinical CROs and vendors.
• Accountable for meeting clinical operational deliverables in accordance with timeline, cost and quality requirements. Proactively communicates progress, issues or changes that may impact timeline, cost of quality clinical programs to all stakeholders.
• Writes or takes active part in preparation, review and approval of clinical documentation such as informed consent forms, clinical protocols, Investigator Brochure, Clinical Monitoring Plan and Project Plan. Maintains the Trial Master File.
• Maintains close working relationships with clinical sites and their personnel to establish efficient conduct and monitoring of clinical studies to ensure quality data and on time execution.
• Oversees activities leading to GCP audits and regulatory inspections related to clinical trial conduct
• Ensures adherence of the clinical team to ICH, GCP, company SOPs and other applicable regulations.
• Delivers reports and presentations on the progress and the findings of the clinical research programs.
• Monitors for safety signals in clinical trials and immediately reports them to a CMO and Chief Development Officer (CDO).
• Represents Clinical Operations on cross-functional project teams, both internal and external.
• Develops and maintains strong, collaborative relationships with key stakeholders within the company.

Qualifications
• Advanced degree in a scientific discipline (M.Sc or PharmD) is preferred.
• 15+ years of clinical operations experience in pharma or biotech companies.
• Extensive clinical operations experience across Phase I-III clinical trials.
• Formal training on and strong command of ICH, GCP, and other relevant regulatory guidelines.
• Excellent project management skills that include implementing plans for site activation, patient enrollment, site monitoring, data management, and drug supply.
• Proven track record in overcoming operational challenges such as implementing protocol amendments and dealing with protocol deviations.
• Strong collaborative, communication and interpersonal skills. Creative problem-solver.
• Proven ability to productively interact with medical personnel at the site level.
• Superior attention to detail, coordination, organizational, and time management skills.
• Ability to communicate clinical information and timelines to internal and external stakeholders.

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.