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About Morphic Therapeutic

Morphic Therapeutic is a biopharmaceutical company developing a new generation of oral integrin therapies for the treatment of serious chronic diseases, including autoimmune, cardiovascular and metabolic diseases, fibrosis and cancer. In collaboration with AbbVie, Janssen and Schrödinger, Morphic is advancing its pipeline and discovery activities using its proprietary MInT technology platform which leverages the Company’s unique understanding of integrin structure and biology. For more information, visit www.morphictx.com.

Morphic is advancing both partnered and fully-owned oral integrin therapeutic candidates into the clinic with an anticipated first IND filing mid-2020. Our immediate focus is on the areas where the clinical activity of antibody inhibitors of integrins is precedented, thus enabling a rapid path to clinical proof-of-concept.

The Morphic Therapeutic office is located in the AstraZeneca BioHub in Waltham, MA. We are seeking a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Job description

Morphic Therapeutic is seeking an accomplished, innovative, and motivated Protein Scientist/Engineer.  The position will be part of the world-class Molecular Discovery Group at Morphic, working together towards transformative therapeutics for autoimmune, fibrotic diseases, and immuno-oncology. The successful candidate will be responsible for creating novel biologics against disease targets using state-of-the-art antibody discovery technologies.

Responsibilities

  • Working with strategic partners to discover novel therapeutic antibodies for modulating integrin functions
  • Designing and engineering reagents for target identification and validation
  • Designing antibody selection strategies and co-developing functional assays
  • Biophysical and biochemical characterizations of antibody-antigen interactions
  • Production of antibodies for in vivo and in vitro studies
  • Present results (written and oral) to internal and external audiences
  • Mentoring and developing junior staff

Qualifications

  • Ph.D. in Biochemistry, Molecular Biology, Structural Biology, or Bioengineering with a minimum of two years of post-graduate research experience.
  • 2+ years of hands-on experience in yeast/phage display, hybridoma generation, and protein engineering is required.
  •  In-depth knowledge of display technologies and library creation is required.
  • Experience in mammalian protein expression, purification and characterization is highly desirable.
  • Experience in antibody affinity maturation, humanization, developability assessment is a plus.
  • Experience in managing and collaborating with CROs is highly desirable.
  • Skilled in recombinant DNA techniques.
  • Knowledge in protein crystallography, cryo-EM, and structural biology is a plus.
  • Demonstrated abilities of critical and creative thinking.
  • Strong problem-solving track record.
  • Proven interest in mentoring and guiding junior employees.
  • Strong organizational, interpersonal and communication skills are required.

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

Click Here to Apply Now!

 

About Morphic Therapeutic

Morphic Therapeutic is a biopharmaceutical company developing a new generation of oral integrin therapies for the treatment of serious chronic diseases, including autoimmune, cardiovascular and metabolic diseases, fibrosis and cancer. In collaboration with AbbVie, Janssen and Schrödinger, Morphic is advancing its pipeline and discovery activities using its proprietary MInT technology platform which leverages the Company’s unique understanding of integrin structure and biology. For more information, visit www.morphictx.com.

Morphic is advancing both partnered and fully-owned oral integrin therapeutic candidates into the clinic with an anticipated first IND filing mid-2020. Our immediate focus is on the areas where the clinical activity of antibody inhibitors of integrins is precedented, thus enabling a rapid path to clinical proof-of-concept.

The Morphic Therapeutic office is located in the AstraZeneca BioHub in Waltham, MA. We are seeking a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Job Description:

Reporting to the Chief Medical Officer, the primary responsibility of the Clinical Scientist is to provide technical support to one or more clinical programs to ensure the successful design and implementation of Clinical Development Plans (CDPs).  Main responsibilities include supporting the Medical Lead on clinical trial design, medical and safety monitoring, including the ability to analyze and synthesize assessments and information as it relates to study conduct and/or subject safety, clinical data analysis (including collaboration with our Translation group on Biomarker data analysis and strategy), and contributing to regulatory submissions, publications, and presentations. This position will also importantly collaborate with the clinical development team on the review, analysis, and interpretation of study results, including exploratory endpoints, and assure appropriate data review, next phase trial planning, and accurate data reporting and analysis.  Over time, this individual may be called upon to build out and lead a full clinical science function commensurate with Morphic clinical program needs.

Essential Functions:

  • Contribute to the planning and design of clinical studies, in addition to contributing to the creation of CDPs in accordance to corporate objectives
  • Contribute to the clinical oversight and medical review of clinical trial data in collaboration with the Medical Lead and/or Medical Monitor during the conduct of the study
  • Based on program and resource needs, the clinical scientist may assist with and/or assume the operational leadership for certain studies
  • Work in close collaboration with Clinical Operations to ensure translation of the clinical protocol into operational deliverables, including but not limited to performing ongoing review and analysis of clinical study data and preparing/reviewing study plans (i.e., Medical Monitoring, Medical Data Review, Safety Management, etc.)
  • Contribute and coordinate the writing and revision of clinical documents, such as study protocols, clinical study reports, investigator brochures, and other materials for regulatory submission
  • Contribute to responses pertaining to clinical questions from regulatory agencies and/or ethics committees
  • Provide support to advisory boards, consultant meetings and investigator meetings, including preparation and delivery of presentations
  • Prepare data and contributing to scientific publications including posters, abstracts and manuscripts
  • Establish good working relationships with external scientific advisors, thought leaders, clinical investigators, and external partners
  • Investigate new disease areas for the application of oral integrin inhibitors
  • Perform literature searches and critically review and summarize the relevant scientific, drug development, and medical literature to support new clinical trial design as well as the development of clinical and/or regulatory documents
  • Support preparation of scientific material for conference presentations or publications
  • Contribute to the development of SOPs and associated guidelines and templates
  • Monitor departmental compliance with required training and adherence to all corporate and departmental SOPs, GCP/ICH guidelines and Quality procedures

Working alongside the CMO and/or Medical Director, the successful candidate will take a leadership role within the clinical development team on the review, analysis, and interpretation of study results, including exploratory endpoints, and assure appropriate data review, next phase trial planning, and accurate data reporting and analysis.

At a personal level it is critical that this individual integrate into the company’s culture of Craftsmanship, Tenacity, Teamwork, Integrity, and Compassion. The preferred candidate will possess strong interpersonal, organizational, planning and communication (oral and written) skills. It is paramount that this person has unquestionable integrity and the highest ethical standards. Furthermore, it is expected that this individual will possess a sense of urgency, and a penchant for delivering the highest quality output and driving results in timely fashion. To that end, the (Sr) Medical Director, Clinical Development must have the following qualities and characteristics:

  • Flexible and adaptable style with a willingness and eagerness to take on challenges;
  • Ability to work as a true team player and be effective in a collaborative culture;
  • Strong leadership and motivational capabilities;
  • Ability to instill and quickly earn trust among teams;
  • Deep thinker who can articulate options for ambiguous situations and execute on decisions with full understanding of potential outcomes;
  • Excellent communication skills, both oral and written.

 

Qualifications:

Required:

  • Advanced degree in a scientific biomedical discipline
  • 7+ years of biotech/pharmaceutical/clinical experience and knowledge of the drug development process with 3+ years in clinical
  • Experience working with medical monitors, R&D functions, regulatory affairs, program management, quality assurance, thought leaders, and clinical investigators
  • Excellent communication (oral and written), analytical, organizational, and project management skills
  • Ability to think strategically and creatively, function independently, deliver on timelines, have strategic insights and have a detailed knowledge of the activities, and procedures involved in clinical drug development
  • Strong ability to work collaboratively in a matrix environment and to foster relationships
  • A solid understanding of ICH guidelines, GXP, and relevant regulatory requirements
  • Ability to travel 20% (post-COVID Restrictions)

Desired

  • Doctorate-level degree
  • Experience with global clinical studies
  • Experience with clinical development in the gastroenterology, hepatology (e.g. IBD and/or PSC) and pulmonary therapeutic areas
  • Demonstrated expertise with developing and implementing biomarkers and translational medicine strategies in early and late stage clinical development and mechanistic profiling programs
  • Experience with critical regulatory submissions (e.g. IND, NDA/BLA)

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K, and a generous vacation and holiday schedule.

 

 

Click Here to Apply Now!

 

About Morphic Therapeutic

Morphic Therapeutic is a biopharmaceutical company developing a new generation of oral integrin therapies for the treatment of serious chronic diseases, including autoimmune, cardiovascular and metabolic diseases, fibrosis and cancer. In collaboration with AbbVie, Janssen and Schrödinger, Morphic is advancing its pipeline and discovery activities using its proprietary MInT technology platform which leverages the Company’s unique understanding of integrin structure and biology. For more information, visit www.morphictx.com.

Morphic is advancing both partnered and fully-owned oral integrin therapeutic candidates into the clinic with an anticipated first IND filing mid-2020. Our immediate focus is on the areas where the clinical activity of antibody inhibitors of integrins is precedented, thus enabling a rapid path to clinical proof-of-concept.

The Morphic Therapeutic office is located in the AstraZeneca BioHub in Waltham, MA. We are seeking a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Job Description

Reporting to the Chief Medical Officer, the primary responsibility of the Gastroenterology (Sr./Exe.) Medical Director is to provide medical leadership and guidance for Morphic’s clinical development programs within the GI therapeutic area.  This position will support the overall program development strategy and program goals ensuring the highest scientific/medical standards are met, including the achievement of goals that are consistent with the overall corporate vision, mission and objectives. S/he will take the lead on clinical trial design, medical and safety monitoring, including the ability to, in collaboration with clinical science and safety functions,  analyze and synthesize assessments and information as it relates to study conduct and/or subject safety, clinical data analysis (including collaboration with our Translation group on Biomarker data analysis and strategy), and contributing critical medical/clinical inputs into regulatory submissions, publications, and presentations.  Specific roles of this position will include:

Essential Functions:

  • Initiating, communicating, and executing well-conceived clinical development plans in support of the discovery, development and commercial mission of Morphic
  • Responsible for the strategic and operational medical input to the design, planning, initiation, completion, analysis and reporting of clinical trials in the GI therapeutic area
  • Providing clinical input on all IND and NDA/BLA preparation activities including data collection, database lock, analysis and write-up of biomarker and pharmacodynamic endpoints
  • Communicating Morphic’s clinical development goals, clinical trial plans and data, as well as clinical program accomplishments to the external community, investigators, key opinion leaders and corporate partners
  • Participating in, and provide clinical support to business development activities on an as-needed basis

Working alongside the CMO, the successful candidate will take a leadership role within the clinical development team on the review, analysis, and interpretation of study results, including exploratory endpoints, and assure appropriate data review, next phase trial planning, and accurate data reporting and analysis.  Over time, this individual may be called upon to build out and lead a full GI clinical development function and programs commensurate with Morphic clinical program needs.

In terms of professional experience, we are seeking an individual who should possess significant experience in clinical development with track record of publications in peer-reviewed journals. This person should have knowledge of clinical development, the FDA, international global clinical trial regulations and good clinical practices (GCP) guidelines. Preference will be given to candidates who have previous experience with drug development within the pharmaceutical or biotechnology industry, particularly at companies addressing indications within the GI space.

At a personal level it is critical that this individual integrate into the company’s culture of Craftsmanship, Tenacity, Teamwork, Integrity, and Compassion. The preferred candidate will possess strong interpersonal, organizational, planning and communication (oral and written) skills. It is paramount that this person has unquestionable integrity and the highest ethical standards. Furthermore, it is expected that this individual will possess a sense of urgency, and a penchant for delivering the highest quality output and driving results in timely fashion. To that end, the (Sr./Exe.) Medical Director, Clinical Development must have the following qualities and characteristics:

  • Flexible and adaptable style with a willingness and eagerness to take on challenges;
  • Ability to work as a true team player and be effective in a collaborative culture;
  • Strong leadership and motivational capabilities;
  • Ability to instill and quickly earn trust among teams;
  • Deep thinker who can articulate options for ambiguous situations and execute on decisions with full understanding of potential outcomes;
  • Excellent communication skills, both oral and written.

Qualifications:

Required:

  • MD or MD/PhD
  • Gastroenterology Fellowship-Trained
  • Biotech/pharmaceutical/clinical experience and knowledge of the drug development and clinical trial processes
  • Experience working with R&D functions, regulatory affairs, quality assurance, thought leaders, and clinical investigators
  • Excellent communication (oral and written) and analytical skills
  • Ability to think strategically and creatively, function independently, deliver on timelines, have strategic insights and have a detailed knowledge of the activities, and procedures involved in clinical drug development
  • Strong ability to work collaboratively in a matrix environment and can foster relationships
  • Good understanding of ICH, GCP, and relevant regulatory requirements
  • Ability to travel 30% (post-COVID Restrictions)

Desired:

  • Medical Monitor experience within clinical development in the gastroenterological (e.g. IBD and/or PSC) area
  • Demonstrated expertise with developing and implementing biomarkers and translational medicine strategies in early and late stage clinical development and mechanistic profiling programs
  • Experience with critical regulatory submissions (e.g. IND, NDA/BLA)

 

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

 

Click Here to Apply Now!

About Morphic Therapeutic

Morphic Therapeutic is a biopharmaceutical company developing a new generation of oral integrin therapies for the treatment of serious chronic diseases, including autoimmune, cardiovascular and metabolic diseases, fibrosis and cancer. In collaboration with AbbVie, Janssen and Schrödinger, Morphic is advancing its pipeline and discovery activities using its proprietary MInT technology platform which leverages the Company’s unique understanding of integrin structure and biology. For more information, visit www.morphictx.com.

Morphic is advancing both partnered and fully-owned oral integrin therapeutic candidates into the clinic with an anticipated first IND filing mid-2020. Our immediate focus is on the areas where the clinical activity of antibody inhibitors of integrins is precedented, thus enabling a rapid path to clinical proof-of-concept.

The Morphic Therapeutic office is located in the AstraZeneca BioHub in Waltham, MA. We are seeking a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Job Description

Morphic Therapeutic is seeking a Research Associate with in vitro and in vivo skills for immunology, pre-clinical research in the areas of inflammation and autoimmunity. The successful candidate will join a dynamic, multi-disciplinary team of scientists, playing a key role to evaluate new immunotherapeutic strategies and drug candidates. The candidate is expected to be multi-tasking and able to execute experiments with strong attention to detail under supervision. The candidate should have high dexterity, be highly motivated, organized, creative and flexible, and collaborate effectively in a team environment.

Responsibilities include but are not limited to:

  • Perform standard procedures in live rodent models
  • Animal study monitoring, necropsy procedures, and downstream processing of samples
  • Isolate and characterize different subsets of primary human and mouse immune cells
  • Perform mammalian cell culture, transfection, Western blot, ELISA, RT-PCR, and multicolor flow cytometry
  • Perform mechanistic studies to characterize the cellular pathways impacted by inhibition of integrin targets
  • Analyze experimental results for presentations to peers and management

Qualifications:

B.Sc. degree with industry or academic experience in biology, immunology, or related field.

Required qualifications and skills:

  • In vivo skills including routine animal handling
  • Basic lab experience in life sciences, in vitro or in vivo
  • Background in immunology, cell biology, biochemistry
  • Demonstrated ability for multi-tasking and high productivity
  • Ability to independently follow Standard Operating Procedures (SOPs)
  • Fast learner and show curiosity in new techniques
  • Excited to be in a lab-based role

Preferred skills:

  • Hands-on experience with molecular and cell biology methodologies and cellular immunology
  • Experience with culturing mammalian cells
  • Prior experience monitoring in vivo disease models

The above statements are intended to describe the general nature and level of work being performed. They are not intended to be construed as an exhaustive list of all responsibilities.

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.