Opportunities

If you are interested in a career at Morphic please submit your CV below.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates.  Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors.  In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic.  Last October, we announced a collaboration with AbbVie on a subset of our fibrosis programs. Under the terms of the agreement, AbbVie paid Morphic an upfront payment of $100 million for exclusive license options on product candidates directed at multiple targets. Morphic retains co-development rights in liver indications. Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated.  The combination of Morphic’s deep integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications.  In addition, we recently announced that it has entered into a research and development collaboration with Janssen Biotech, Inc. (Janssen) to discover and develop novel integrin therapeutics for patients with conditions not adequately addressed by current therapies. Johnson & Johnson Innovation LLC facilitated the transaction. The collaboration focuses on several undisclosed integrin targets and will explore both inhibitors and activators of integrin function.  Under the terms of the agreement, the companies will collaborate through preclinical development to identify and advance candidates. Morphic is located in the AstraZeneca BioHub in Waltham, MA. We seek a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Job description

Morphic Therapeutic is seeking a skilled medicinal chemist to join our team. The role will suit an individual with a passion for science, strong problem-solving skills, and a sense of urgency to deliver in an early stage, fast paced biotech company.

Responsibilities

  • Provide chemistry leadership for project teams
  • Utilize modern drug design techniques to design inhibitors based on structural insights, in silico modeling and physiochemical properties
  • Work closely with Schrödinger scientists to utilize structure-based drug design and computational predictions to advance projects quickly and efficiently
  • Communicate and enable external chemistry teams to solve synthetic issues in an efficient manner
  • Work closely with internal chemists to advance projects quickly in a collaborative manner
  • As a key member of Morphic’s medicinal chemistry team, positively influence Morphic’s overall scientific and corporate culture

Qualifications

  • Ph.D. (or equivalent) in chemistry with 5+ years of research experience
  • Deep understanding of synthetic and medicinal chemistry, as evidenced by a record of achievement
  • Track record of innovation and creative problem solving
  • Previous project leadership experience preferred
  • Experience in structure-based drug design and working with computational chemists/ structural biologists preferred
  • Flexible, tenacious, open minded, creative and inclusive
  • Ability to guide external synthetic organic chemistry at CROs
  • Exceptional communication and interpersonal skills, known as an excellent team member working together to solve difficult scientific challenges

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates.  Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors.  In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic.  Last October, we announced a collaboration with AbbVie on a subset of our fibrosis programs. Under the terms of the agreement, AbbVie paid Morphic an upfront payment of $100 million for exclusive license options on product candidates directed at multiple targets. Morphic retains co-development rights in liver indications. Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated.  The combination of Morphic’s deep integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications.  In addition, we recently announced that it has entered into a research and development collaboration with Janssen Biotech, Inc. (Janssen) to discover and develop novel integrin therapeutics for patients with conditions not adequately addressed by current therapies. Johnson & Johnson Innovation LLC facilitated the transaction. The collaboration focuses on several undisclosed integrin targets and will explore both inhibitors and activators of integrin function.  Under the terms of the agreement, the companies will collaborate through preclinical development to identify and advance candidates. Morphic is located in the AstraZeneca BioHub in Waltham, MA. We seek a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Job description

Morphic Therapeutic is seeking a highly motivated Research Associate/Sr. Research Associate in Biochemistry and Structural Biology. The successful candidate will be responsible for expressing and purifying proteins of the Integrin family for use in downstream applications such as assays, structural biology, and biophysical characterization. The position will be part of a multi-disciplinary team at Morphic, working together towards transformative small molecule therapeutics for autoimmune and fibrotic diseases. A strong knowledge of biochemistry is required, lab experience in the areas of tissue culture and protein purification being preferred.

Responsibilities

  • Design and execute experiments to support research activities and project goals
  • Responsible for generating and characterizing high quality protein samples for compound activity profiling and protein crystallography
  • Maintain mammalian tissue cultures and laboratory equipment
  • Work within a multi-functional team and collaborate with multiple groups including Biology, Chemistry, and Pharmacology

Qualifications

  • BS/MS in biochemistry/biophysics/molecular cell biology or related discipline, with 2+ years of research experience.
  • Experience in protein expression and purification
  • Experience with AKTA chromatography systems, SDS-PAGE, and western blot.
  • Knowledge in basic tissue culture techniques is a plus.
  • Knowledge in X-ray crystallography and structural biology is a plus.
  • Must demonstrate a good understanding of scientific principles, experimental design, and proper laboratory techniques
  • Excellent communication, interpersonal, and organizational skills

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates.  Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors.  In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic.  Last October, we announced a collaboration with AbbVie on a subset of our fibrosis programs. Under the terms of the agreement, AbbVie paid Morphic an upfront payment of $100 million for exclusive license options on product candidates directed at multiple targets. Morphic retains co-development rights in liver indications. Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated.  The combination of Morphic’s deep integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications.  In addition, we recently announced that it has entered into a research and development collaboration with Janssen Biotech, Inc. (Janssen) to discover and develop novel integrin therapeutics for patients with conditions not adequately addressed by current therapies. Johnson & Johnson Innovation LLC facilitated the transaction. The collaboration focuses on several undisclosed integrin targets and will explore both inhibitors and activators of integrin function.  Under the terms of the agreement, the companies will collaborate through preclinical development to identify and advance candidates. Morphic is located in the AstraZeneca BioHub in Waltham, MA. We seek a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Job description

Morphic Therapeutic is seeking a highly motivated DMPK scientist (Sr. Scientist to Principle Scientist depending on qualification). The successful candidate will serve as the DMPK expert on project teams to evaluate underlying ADME mechanisms driving PK properties and to enable small molecule candidate optimization and prediction of clinical dosing regimens. The position will be part of a multi-disciplinary team at Morphic, working together towards transformative small molecule therapeutics for autoimmune and fibrotic diseases. A strong knowledge in drug transporter sciences and enzymology is required.

Responsibilities

  • Design and supervise CROs for routine and mechanistic PK and ADME studies that enable compound optimization and decision making
  • Integrate PK and PKPD information and provide guidance to internal and external collaborators on the design and data interpretation for PK and PKPD studies
  • Partner closely with chemistry and biology colleagues to build compound screen and optimization strategies through mechanistic and quantitative understanding of PK and PD properties of drug candidates
  • Interface with development colleagues and lead the preparation of PK, ADME, and drug interaction data package for regulatory filings

Qualifications

  • Ph.D. in Drug Metabolism, Pharmacokinetics, Pharmaceutics or other relevant fields with >5 years of experience in the biopharmaceutical industry
  • Strong knowledge of drug transporters, ADME concepts, and bioanalytical principles is required
  • Experience in human PK prediction methodologies including allometry, IVIVC or PBPK
  • Experience in regulatory filing, in vitro and in vivo ADME assays and managing/collaborating with CROs
  • Strong organization, multi-tasking, interpersonal and communication skills

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates.  Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors.  In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic.  Last October, we announced a collaboration with AbbVie on a subset of our fibrosis programs. Under the terms of the agreement, AbbVie paid Morphic an upfront payment of $100 million for exclusive license options on product candidates directed at multiple targets. Morphic retains co-development rights in liver indications. Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated.  The combination of Morphic’s deep integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications.  In addition, we recently announced that it has entered into a research and development collaboration with Janssen Biotech, Inc. (Janssen) to discover and develop novel integrin therapeutics for patients with conditions not adequately addressed by current therapies. Johnson & Johnson Innovation LLC facilitated the transaction. The collaboration focuses on several undisclosed integrin targets and will explore both inhibitors and activators of integrin function.  Under the terms of the agreement, the companies will collaborate through preclinical development to identify and advance candidates. Morphic is located in the AstraZeneca BioHub in Waltham, MA. We seek a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Job description

Morphic Therapeutic is seeking an accomplished, innovative, and motivated Protein Scientist/Engineer. The position will be part of world-class research team at Morphic, working together towards transformative therapeutics for autoimmune, fibrotic diseases, and immuno-oncology. The successful candidate will be responsible for creating novel biologics against disease targets using state-of-the-art yeast libraries.

Responsibilities

  • Working with a strategic academic partner to establish a yeast display platform
  • Identifying and engineering reagents for target identification and validation
  • Designing selection strategies and co-developing functional assays
  • Biophysical and biochemical characterizations of antibody-antigen interaction
  • Production of antibody for in vivo and in vitro studies
  • Present results (written and oral) to internal and external audiences
  • Mentoring and developing junior staff

Qualifications

  • Ph.D. in Biochemistry, Molecular Biology, Structural Biology, or Bioengineering with a minimum of two years of post-graduate research experience.
  • 2+ years of hands-on experience in yeast display and/or phage display, and protein engineering is required.
  • In-depth knowledge of display technologies and libraries is required.
  • Experience in mammalian protein expression, purification and characterization is highly desirable.
  • Experience in antibody affinity maturation and other display technologies is a plus.
  • Highly-skilled in recombinant DNA techniques
  • Knowledge in protein crystallography, cryo-EM, and structural biology is highly desirable.
  • Demonstrated abilities of critical and creative thinking
  • Strong problem-solving track record
  • Proven interest in mentoring and guiding junior employees
  • Experience in managing and collaborating with CROs is a plus
  • Strong organization, interpersonal and communication skills are required.

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates.  Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors.  In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic.  Last October, we announced a collaboration with AbbVie on a subset of our fibrosis programs. Under the terms of the agreement, AbbVie paid Morphic an upfront payment of $100 million for exclusive license options on product candidates directed at multiple targets. Morphic retains co-development rights in liver indications. Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated.  The combination of Morphic’s deep integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications.  In addition, we recently announced that it has entered into a research and development collaboration with Janssen Biotech, Inc. (Janssen) to discover and develop novel integrin therapeutics for patients with conditions not adequately addressed by current therapies. Johnson & Johnson Innovation LLC facilitated the transaction. The collaboration focuses on several undisclosed integrin targets and will explore both inhibitors and activators of integrin function.  Under the terms of the agreement, the companies will collaborate through preclinical development to identify and advance candidates. Morphic is located in the AstraZeneca BioHub in Waltham, MA. We seek a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Description

Morphic Therapeutic is currently seeking an experienced scientist to lead drug discovery efforts in the area of autoimmune diseases. The individual should be highly self-motivated and possess deep, scientific knowledge in immunology. Additionally, he/she will have strong technical research skills, have strong written and oral communication skills, and be able to work productively in a collaborative and cross-functional team environment within and outside of Morphic Therapeutic.

Responsibilities

The candidate will be expected to design, plan, and execute experiments in the laboratory and provide scientific and strategic input into the disease portfolio. This will include implementation and development of cellular assays and in vivo models representing relevant mechanisms of disease. The candidate will also be expected to lead discovery projects, coordinate research activities across multiple functional areas, and manage collaborative efforts. The candidate will also be expected to launch and champion new initiatives, driving innovation, and serve as a scientific mentor to junior team members.

Qualifications

Education:

PhD degree in life science with 2-6 years of relevant industry experience in the field of immunology and immune-related diseases. Comparable academia experienced applicants may be considered.

Required qualifications and skills:

  • Deep scientific knowledge in immunology and autoimmune diseases
  • Experience in studying cell-cell mechanisms of immunology
  • Proficient in preparing samples and running high-dimensional, flow cytometry
  • In vitro skills including general molecular and cellular biology, cell-based assay, assay development, and ex vivo tissue analysis
  • In vivo skills including animal handling, dosing, sampling, and development of relevant in vivo models
  • Demonstrated ability for multi-tasking and high productivity
  • Demonstrated ability for strategic thinking and problem-solving
  • Ability to organize and communicate complex research ideas or results in a concise manner to stakeholders with diverse backgrounds
  • Experience in managing and mentoring report to a high level of performance

Preferred skills:

  • Experience in rodent models of Inflammatory Bowel Disease
  • Experience in managing external collaborations

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates.  Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors.  In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic.  Last October, we announced a collaboration with AbbVie on a subset of our fibrosis programs. Under the terms of the agreement, AbbVie paid Morphic an upfront payment of $100 million for exclusive license options on product candidates directed at multiple targets. Morphic retains co-development rights in liver indications. Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated.  The combination of Morphic’s deep integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications.  In addition, we recently announced that it has entered into a research and development collaboration with Janssen Biotech, Inc. (Janssen) to discover and develop novel integrin therapeutics for patients with conditions not adequately addressed by current therapies. Johnson & Johnson Innovation LLC facilitated the transaction. The collaboration focuses on several undisclosed integrin targets and will explore both inhibitors and activators of integrin function.  Under the terms of the agreement, the companies will collaborate through preclinical development to identify and advance candidates. Morphic is located in the AstraZeneca BioHub in Waltham, MA. We seek a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

 

Job description

Morphic Therapeutic is seeking a highly energetic and organized individual to manage operations of the labs at Morphic Therapeutic. The candidate must be self-motivated and able to interact and communicate with multiple lab members. Comfort working in a lab setting is essential.

Responsibilities

Responsibilities include but are not limited to:

  • Ensuring items are fully stocked
  • Organizing the preventative maintenance on all the equipment as well as organizing the repair of broken lab equipment
  • Maintaining a clean and organized lab environment
  • Managing the chemical inventory
  • Work with a safety consultant to ensure that all labs are complying with best safety practices

Qualifications

  • Familiarity with lab environment
  • Bachelor’s degree is preferred but not required

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates.  Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors.  In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic.  Last October, we announced a collaboration with AbbVie on a subset of our fibrosis programs. Under the terms of the agreement, AbbVie paid Morphic an upfront payment of $100 million for exclusive license options on product candidates directed at multiple targets. Morphic retains co-development rights in liver indications. Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated.  The combination of Morphic’s deep integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications.  In addition, we recently announced that it has entered into a research and development collaboration with Janssen Biotech, Inc. (Janssen) to discover and develop novel integrin therapeutics for patients with conditions not adequately addressed by current therapies. Johnson & Johnson Innovation LLC facilitated the transaction. The collaboration focuses on several undisclosed integrin targets and will explore both inhibitors and activators of integrin function.  Under the terms of the agreement, the companies will collaborate through preclinical development to identify and advance candidates. Morphic is located in the AstraZeneca BioHub in Waltham, MA. We seek a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Job description

Morphic Therapeutic is seeking a highly motivated, experienced, and accomplished computational chemist. This person will work closely with Schrodinger scientists in a valued and successful collaboration to advance multiple early – late stage projects. At the same time, the successful candidate will build internal capabilities at Morphic to compliment Schrodinger tools and efforts, as well as interacting with other collaborators. An additional responsibility will be to set the company strategy in chemoinformatics, and address future needs in this area. As an integral member of discovery project teams, the candidate will work collaboratively with multiple scientists in medicinal chemistry, biology and DMPK to advance clinical candidates in areas of high medical need.

Responsibilities

  • Leader of computational chemistry and chemoinformatics at Morphic
  • Build strong relationships with Schrodinger scientists and work in a highly collaborative manner
  • Work closely with internal medicinal chemists, biologists, DMPK and other scientists to set project strategy
  • Determine what additional computational and chemoinformatics tools are needed to compliment current resources
  • Work with pharma collaborators to coordinate diverse project teams
  • Advance projects through use of these tools directly towards clinical candidates to impact patients

Qualifications

  • PhD. in relevant scientific field and 10+ years of industry experience
  • Deep knowledge of multiple computational chemistry and chemoinformatics platforms
  • Regarded as a computational chemistry thought leader
  • Excellent written and oral communication skills
  • General knowledge of medicinal chemistry and DMPK
  • Demonstrated ability to think logically and critically to build computational hypotheses across multiple projects
  • Key contributor to discovery project teams while forming productive working relationships
  • Successful track record of advancing clinical candidates collaboratively in a positive team environment
  • Experience with chemoinformatics, data storage, and analysis

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates.  Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors.  In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic.  Additionally, in the last 3 months, the company has forged two transformational partnerships with Abbvie and Janssen that include >$100M upfront with future milestones.  Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated.  The combination of Morphic’s deep Integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications.  Morphic’s laboratories are located in the AstraZeneca BioHub in Waltham, MA.  We seek a highly talented and motivated People Operations/Payroll Coordinator to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity!

Description

The People Operations Administrator is a key member of Morphic’s People Operations team and will serve as a resource to employees for all HR areas including, payroll, employee benefits, onboarding, HR programs, policies, communications and HR administration. The People Operations Administrator will interact with all levels of employees to exchange information, and problem solve. The ideal candidate is personable, extremely organized, keeps calm under pressure, and thrives in a fast-paced environment.

Responsibilities include but not limited to:

  • Manage bi-monthly payroll, ensuring that new hires, terminations, and compensation changes are handled properly
  • Ensure that bonuses and other types of variable compensation are calculated and paid appropriately
  • Manage benefit programs and employee benefits changes, including enrollments, terminations
  • Maintain employee personnel records and HRIS systems to ensure compliance and accurate employee information
  • Coordinate onboarding, employee reward program and other HR related programs
  • Provides stellar customer support to internal and external customers with the willingness to always to that extra mile to ensure customer satisfaction
  • Participates in additional departmental projects and priorities as requested
  • This position will also include light administrative work

Qualifications

Education/Experience:

  • Bachelor’s degree in Human Resources or a related filed.
  • 1-3 years of experience in business administration, preferably as an HR Coordinator

Required Qualifications and Skills:

  • Strong organizational skills and time management
  • Meticulous attention to detail
  • Able to work well in a team environment as well as independently
  • Excellent interpersonal and written and verbal communication skills
  • Works well under pressure and meets tight deadlines
  • Display flexibility and willingness to take on new responsibilities to assist with various projects as needed

Preferred Skills/Certifications:

  • Experience with HRIS management highly preferred
  • PHR or SHRM-CP certification
  • Experience in the Biotechnology industry

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates.  Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors.  In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic.  Additionally, in the last 3 months, the company has forged two transformational partnerships with Abbvie and Janssen that include >$100M upfront with future milestones.  Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated.  The combination of Morphic’s deep Integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications.  Morphic’s laboratories are located in the AstraZeneca BioHub in Waltham, MA.  We seek a highly talented and motivated scientist to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity!

Job Description:

Morphic is currently seeking a highly motivative and experienced bioinformatics scientist to work on a variety of genomics projects in the field of autoimmunity, immune-oncology, and fibrosis. This position will work on multiple internal and external datasets for target discovery and hypothesis generation.

RESPONSIBILITIES

A successful candidate will join our highly collaborative multi-functional team and use a variety of computational algorithms and tools for the discovery of new targets. Primary responsibilities will be to:

  • Develop or apply new tools, algorithms, and data mining techniques for the integrative analysis of large genomic datasets, including but not limited to single cell RNAseq and human genetics data, from both internal and external data sources
  • Extract information and knowledge from multi-dimensional genomics data-sets and annotations
  • Develop and implement innovative analysis strategies to generate meaningful hypotheses for new therapeutic targets or mechanism of actions of drug candidates
  • Prioritize targets and contribute to target validation study designs

QUALIFICATIONS

  • PhD in Bioinformatics, Biology, or equivalent, with a minimum of 3 years of working experience in computational biology and genomics in academia or industry
  • Strong scientific and technical background in biology (preferably in immunology) and NGS (preferably in single cell genomics)
  • Familiarity with biological pathways and network analyses
  • Proficiency with R, Python or other scripting language for statistical computing and graphics
  • Proven ability to analyze complexed datasets and transform information to knowledge
  • Ability to develop intuitive visualization tools for large datasets
  • Familiarity with cutting-edge bioinformatic and computational tools
  • Highly independent with demonstrated strong scientific curiosity
  • Effective communication skills with strong ability to explain computational approaches and data to non-computational scientists

Preferred but not required:

  • Experience in relational databases
  • Hands-on experience with machine learning algorithms and data mining methods
  • Experience in using NGS data to assess antibody library diversity and affinity maturation

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Dr. Timothy A. Springer, Morphic has developed an exclusive platform that facilitates the rapid discovery of clinical candidates.  Morphic was created in 2015 and raised $51.5M in 2016 from top tier investors.  In 2018, Morphic Therapeutic completed an $80 million Series B financing round and formed a collaboration with Abbvie Inc. focused on the exploration of TGF-β biology in fibrotic diseases. In 2019 Morphic has formed a collaboration with Janssen Biotech, a Johnson and Johnson company to explore the potential of integrin inhibitor and activators in multiple diseases. Currently, we are advancing both partnered and fully-owned oral integrin therapeutic candidates into the clinic.  Integrin dysregulation is involved in multiple diseases that span including inflammation, fibrosis, vascular diseases, and cancer. Our immediate focus is on the areas where the clinical activity of antibody inhibitors of integrins is precedented thus enabling a rapid path to clinical proof-of-concept.

Morphic’s laboratories are located in the AstraZeneca BioHub in Waltham, MA.  We are seeking a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Job description

Morphic is searching for a creative, resourceful and dynamic individual to join our growing company as a Director/Senior Director of Regulatory Affairs and Quality Assurance. The successful candidate will guide regulatory strategies for the discovery and development-stage programs. She/he will be responsible for achieving timely, high-quality regulatory submissions, development of Regulatory Operations systems and functions, oversight of the publishing and submission of INDs, IMPDs, briefing packages, safety reports, and other applicable documents. She/he will oversee GXP activities and provide strategic leadership and management of Quality Assurance activities. The ideal candidate will be a self-starter, who will strive in a fast-paced, collaborative environment. She/he will report to the Chief Development Officer.

Responsibilities

Ensures the success of regulatory submissions by regulatory authority requirements of FDA and EMA. Leads activities of the internal team and external vendors and consultants to ensure optimal timing, high quality and effective management of these submissions.

Ensures development of regulatory strategies for Morphic programs. Productively interfaces with the regulatory experts of Morphic partners.  Develops and maintains product technical files.

Acts as subject matter expert with responsibility for training representatives from internal teams. Maintains expert knowledge of regulatory requirements of global regulatory authorities. Instructs the team of relevant changes and implements appropriate regulatory strategies to mitigate risks.

Defines and implements standards and process for regulatory submission management. Oversees compliant archiving of all regulatory documents and global regulatory correspondence.

Ensures all activities and operations are carried out in compliance with local, state, federal, and international regulations and laws governing the quality operations. Implements a quality management system. Manages internal and external GXP audits and ensures continuous audit readiness. Provides leadership of quality functions with an emphasis on product quality, prevention and continuous improvement.

Qualifications

  • 15+ years of experience in the pharmaceutical industry
  • 10+ years Regulatory Affairs experience in drug development activities
  • Extensive experience with small molecule drugs
  • An advanced degree is preferred (MS/Ph.D./PharmD)
  • Proven track record of successful regulatory submission including IND, IMPD, CTA and CTN applications
  • Solid understanding of CTD/eCTD structure and requirements for US FDA submissions coupled with knowledge of international submission requirements in all applicable global regions
  • ISO13485 experience and knowledge of 21 CFR, ICH Q7-Q10, E6
  • Leadership experience in GXP environment
  • Strong interpersonal skills and ability to work effectively within cross-functional teams
  • Strong strategic skills, ability to make complex decisions and to articulate their trade-offs
  • Excellent operational skills including planning, organizing and ability to motivate and lead others
  • Proven track record of forming collaborative relationships to facilitate accomplishing company goals
  • Ability to travel up to 15% of the time

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Dr. Timothy A. Springer, Morphic has developed an exclusive platform that facilitates the rapid discovery of clinical candidates.  Morphic was created in 2015 and raised $51.5M in 2016 from top tier investors.  In 2018, Morphic Therapeutic completed an $80 million Series B financing round and formed a collaboration with Abbvie Inc. focused on the exploration of TGF-β biology in fibrotic diseases. In 2019 Morphic has formed a collaboration with Janssen Biotech, a Johnson and Johnson company to explore the potential of integrin inhibitor and activators in multiple diseases. Currently, we are advancing both partnered and fully-owned oral integrin therapeutic candidates into the clinic.  Integrin dysregulation is involved in multiple diseases that span including inflammation, fibrosis, vascular diseases, and cancer. Our immediate focus is on the areas where the clinical activity of antibody inhibitors of integrins is precedented thus enabling a rapid path to clinical proof-of-concept.

Morphic Therapeutic office is located in the AstraZeneca BioHub in Waltham, MA.  We are seeking a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Job description

The Director/Senior Director of Alliance and Project Management will ensure the smooth functioning of the Morphic alliances with its partners. The successful candidate will foster the team spirit in reaching collaboration objectives and will guide the team members in proactive identification and constructive resolution of collaboration challenges. She/he will manage and mentor Program Managers to high productivity in supporting collaboration objectives. The Director/Senior Director of Alliance and Project Management will additionally coordinate the advancement of the key internal development-stage program. She/he will be responsible for creating integrated program plan, for guiding the team of internal functional experts to maintain disciplined execution through anticipating and solving program challenges, and for the articulation of integrated program strategy to the company leadership.  The ideal candidate will be a self-starter, who will strive in a fast-paced, collaborative environment. She/he will report to the Chief Development Officer.

Responsibilities

  • Manage alliances to ensure that key goals and metrics for each alliance are established, tracked and met;
  • Create and execute on value-maximizing alliance management strategy for each collaboration;
  • Ensure that the governance structure is utilized to drive joint strategic and operational effectiveness;
  • Understand the partner’s people, roles, operating model, decision-making processes and stakeholders;
  • Develop a deep understanding of and serve as an internal expert on contracts guiding the alliances;
  • Understand and communicate how alliance objectives support corporate strategy and portfolio;
  • Proactively articulate alliance issues and possible resolutions to internal and partner stakeholders;
  • Guide the internal team members in the identification and resolution of collaboration challenges;
  • Lead planning for and coordinate execution of the key internal development-stage program;
  • Collaborate with the team to identify opportunities and to address challenges in a timely fashion;
  • Foster alliance and project management understanding and skills across the organization;
  • Manage and mentor Project Managers to high productivity.

Qualifications

  • Advance degree (MS, PhD, MD, PharmD, or MBA) is strongly preferred;
  • 12+ years in the pharmaceutical industry with 3+ years in program and alliance management;
  • Strong management and leadership qualities, ability to collaborate across the functional lines;
  • Extensive experience in small molecule drug development through early clinical development;
  • Demonstrated ability to develop strong relationships with key stakeholders internally and externally;
  • Excellent interpersonal, communication and negotiation skills, ability to manage difficult conversations;
  • Demonstrated skills in strategic planning, risk mitigation, problem-solving and conflict resolution;
  • Knowledge of the structure of IND, CTA and IMPD modules and submission requirements;
  • Superior coordination, organization and presentation skills, both written and oral;
  • Expert in preparation and implementation of project plans created with the input of functional experts;
  • Proven ability to work within a matrix working environment positively impacting the organization;
  • Ability to travel up to 15% of the time.

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies. Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates. Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors. In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic. Last October, we announced a collaboration with AbbVie on a subset of our fibrosis programs. Under the terms of the agreement, AbbVie paid Morphic an upfront payment of $100 million for exclusive license options on product candidates directed at multiple targets. Morphic retains co-development rights in liver indications. Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated. The combination of Morphic’s deep integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications. In addition, we recently announced that it has entered into a research and development collaboration with Janssen Biotech, Inc. (Janssen) to discover and develop novel integrin therapeutics for patients with conditions not adequately addressed by current therapies. Johnson & Johnson Innovation LLC facilitated the transaction. The collaboration focuses on several undisclosed integrin targets and will explore both inhibitors and activators of integrin function. Under the terms of the agreement, the companies will collaborate through preclinical development to identify and advance candidates. Morphic is located in the AstraZeneca BioHub in Waltham, MA. We seek a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Description and Responsibilities

Morphic Therapeutic is currently seeking a Research Associate I with strong in vitro and in vivo skills for fibrosis research. The candidate will work cross-functionally within the organization to contribute to the areas of immunology, fibrosis, and oncology. The candidate is expected to be multi-tasking and able to execute complex experiments with strong attention to detail under daily supervision. The candidate should be highly motivated, creative and flexible, possess strong experimental and technical research skills, have excellent communication skills, and collaborate effectively in a team environment. The responsibilities of the candidate include but are not limited to:

  • Perform standard procedures in live rodent models
  • Perform ex vivo sample analysis
  • Establish in vitro cell-based assays independently for anti-fibrotic compound evaluation
  • Design and conduct mechanism of action studies for targets of interest
  • Analyze experimental results and accurately extract information from the data for presentations to peers and management

Qualifications

Education:

B.Sc. degree with a minimum of 1-2 years of industry or academic experience in biology, pharmacology, or related field.

Required qualifications and skills:

  • In vivo skills including routine animal handling
  • Proficient with necropsy
  • Cellular biology and cell-based assay
  • Ex vivo sample processing and analysis
  • Demonstrated ability for multi-tasking and high productivity
  • Fast learner and show curiosity in new techniques

Preferred skills:

  • Familiarity with rodent models of immunology or fibrosis
  • Experience in rodent compound treatment is a plus

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

Apply Now!