Opportunities

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About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates.  Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors.  In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic.  Last October, we announced a collaboration with AbbVie on a subset of our fibrosis programs. Under the terms of the agreement, AbbVie paid Morphic an upfront payment of $100 million for exclusive license options on product candidates directed at multiple targets. Morphic retains co-development rights in liver indications. Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated.  The combination of Morphic’s deep integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications.  In addition, we recently announced that it has entered into a research and development collaboration with Janssen Biotech, Inc. (Janssen) to discover and develop novel integrin therapeutics for patients with conditions not adequately addressed by current therapies. Johnson & Johnson Innovation LLC facilitated the transaction. The collaboration focuses on several undisclosed integrin targets and will explore both inhibitors and activators of integrin function.  Under the terms of the agreement, the companies will collaborate through preclinical development to identify and advance candidates. Morphic is located in the AstraZeneca BioHub in Waltham, MA. We seek a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Job description

Morphic Therapeutic is seeking a skilled medicinal chemist to join our team. The role will suit an individual with a passion for science, strong problem-solving skills, and a sense of urgency to deliver in an early stage, fast paced biotech company.

Responsibilities

  • Provide chemistry leadership for project teams
  • Utilize modern drug design techniques to design inhibitors based on structural insights, in silico modeling and physiochemical properties
  • Work closely with Schrödinger scientists to utilize structure-based drug design and computational predictions to advance projects quickly and efficiently
  • Communicate and enable external chemistry teams to solve synthetic issues in an efficient manner
  • Work closely with internal chemists to advance projects quickly in a collaborative manner
  • As a key member of Morphic’s medicinal chemistry team, positively influence Morphic’s overall scientific and corporate culture

Qualifications

  • Ph.D. (or equivalent) in chemistry with 5+ years of research experience
  • Deep understanding of synthetic and medicinal chemistry, as evidenced by a record of achievement
  • Track record of innovation and creative problem solving
  • Previous project leadership experience preferred
  • Experience in structure-based drug design and working with computational chemists/ structural biologists preferred
  • Flexible, tenacious, open minded, creative and inclusive
  • Ability to guide external synthetic organic chemistry at CROs
  • Exceptional communication and interpersonal skills, known as an excellent team member working together to solve difficult scientific challenges

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates.  Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors.  In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic.  Last October, we announced a collaboration with AbbVie on a subset of our fibrosis programs. Under the terms of the agreement, AbbVie paid Morphic an upfront payment of $100 million for exclusive license options on product candidates directed at multiple targets. Morphic retains co-development rights in liver indications. Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated.  The combination of Morphic’s deep integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications.  In addition, we recently announced that it has entered into a research and development collaboration with Janssen Biotech, Inc. (Janssen) to discover and develop novel integrin therapeutics for patients with conditions not adequately addressed by current therapies. Johnson & Johnson Innovation LLC facilitated the transaction. The collaboration focuses on several undisclosed integrin targets and will explore both inhibitors and activators of integrin function.  Under the terms of the agreement, the companies will collaborate through preclinical development to identify and advance candidates. Morphic is located in the AstraZeneca BioHub in Waltham, MA. We seek a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Job description

Morphic Therapeutic is seeking an accomplished, innovative, and motivated Protein Scientist/Engineer. The position will be part of world-class research team at Morphic, working together towards transformative therapeutics for autoimmune, fibrotic diseases, and immuno-oncology. The successful candidate will be responsible for creating novel biologics against disease targets using state-of-the-art yeast libraries.

Responsibilities

  • Working with a strategic academic partner to establish a yeast display platform
  • Identifying and engineering reagents for target identification and validation
  • Designing selection strategies and co-developing functional assays
  • Biophysical and biochemical characterizations of antibody-antigen interaction
  • Production of antibody for in vivo and in vitro studies
  • Present results (written and oral) to internal and external audiences
  • Mentoring and developing junior staff

Qualifications

  • Ph.D. in Biochemistry, Molecular Biology, Structural Biology, or Bioengineering with a minimum of two years of post-graduate research experience.
  • 2+ years of hands-on experience in yeast display and/or phage display, and protein engineering is required.
  • In-depth knowledge of display technologies and libraries is required.
  • Experience in mammalian protein expression, purification and characterization is highly desirable.
  • Experience in antibody affinity maturation and other display technologies is a plus.
  • Highly-skilled in recombinant DNA techniques
  • Knowledge in protein crystallography, cryo-EM, and structural biology is highly desirable.
  • Demonstrated abilities of critical and creative thinking
  • Strong problem-solving track record
  • Proven interest in mentoring and guiding junior employees
  • Experience in managing and collaborating with CROs is a plus
  • Strong organization, interpersonal and communication skills are required.

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Dr. Timothy A. Springer, Morphic has developed an exclusive MInT platform that facilitates the rapid discovery of clinical candidates.  Morphic was created in 2015 and raised $51.5M in 2016 from top tier investors.  In 2018, Morphic Therapeutic completed an $80 million Series B financing round and formed a collaboration with Abbvie Inc. focused on the exploration of TGF-β biology in fibrotic diseases. In 2019 Morphic formed a collaboration with Janssen Biotech, a Johnson and Johnson company to explore the potential of integrin inhibitors and activators in multiple diseases. On Jun. 26, 2019 Morphic announced the pricing of its upsized initial public offering of 6,000,000 shares of its common stock at a price to the public of $15.00 per share. The shares are trading on The Nasdaq Global Market under the symbol “MORF”.

Currently, we are advancing both partnered and fully-owned novel oral integrin therapeutic candidates into the clinic.  Integrin dysregulation is involved in multiple diseases, including inflammation, fibrosis, vascular diseases, and cancer. Our immediate focus is on the areas where the clinical activity of antibody inhibitors of integrins is precedented, thus enabling a rapid path to clinical proof-of-concept.

The Morphic Therapeutic office is located in the AstraZeneca BioHub in Waltham, MA.  We are seeking a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Job description

The Vice President of Toxicology and Bioanalysis will be a strategic and operational leader responsible for developing nonclinical safety strategy and for the design and execution of all safety studies from late discovery through the clinical development. The successful candidate will build state-of-art bioanalysis and toxicology functions and lead the group to high productivity. This group will partner with the internal DMPK group to conduct toxicokinetic analysis of drug candidates. The successful candidate will work in a team environment to efficiently complete high-quality Toxicology Risk Assessments to enable rapid advancement of the drug candidates in the Morphic pipeline. She/he candidate will also ensure the group works effectively with internal functions and external resources on toxicology-related issues. This individual will play a critical role in monitoring studies conducted by contract research organizations and will work with a network of external consultants to interpret and communicate the findings, create and deliver documents for regulatory filings, and represent Morphic at meetings with regulatory agencies. She/he will help create and work under company Standard Operating Procedures (SOPs) relevant to the job function. The ideal candidate will be a strong leader, who will excel in a fast-paced, collaborative environment, and who enjoys teaching and mentorship. She/he will report to the Chief Development Officer.

Responsibilities

  • Design and implement toxicology programs for drug candidates from pilot studies through marketing approval
  • Partner with internal Drug Metabolism and Pharmacokinetics group to perform toxicokinetic analysis
  • Implement robust bioanalytical methods to support evaluation of the drug candidates
  • Ensure appropriate conduct, accuracy and timely execution of the studies, review of the data and preparation of the submission-ready documents for regulatory authorities worldwide
  • Represent the company in meetings with regulatory authorities and with partners as needed
  • Perform due diligence reviews on potential in-license drug development candidates
  • Contribute to the selection and advancement of optimal drug candidates for clinical development
  • Provide key insights into understanding the safety, tolerability and safety margins of drug candidates
  • Act as a scientific resource, providing knowledge and expertise to cross-functional project teams
  • Serve as a trusted expert of the safety aspects of drug development and devise monitoring strategies
  • Work diligently and effectively to meet aggressive timelines and to address program issues as they arise
  • Collaborate with functions in discovery and development and work with partners to advance programs
  • Build strong expert networks and integrate their input in solving drug development challenges
  • Manage, coach and mentor direct reports and effectively delegate responsibilities to direct reports
  • Play a critical role in advancing corporate initiatives as a member of the executive leadership team
  • Ensure adherence to relevant regulatory requirements and company SOPs

Qualifications

  • PhD in Toxicology, Pathology, Pharmacology, DABT certification; DVM or diplomate ACVP is a plus
  • 18+ years of relevant pharmaceutical industry experience with 10+ years of function leadership
  • Extensive experience in small molecule drug development with the focus on early development
  • Track record of managing toxicology programs, preparation of regulatory documents and filings
  • In-depth knowledge of GLP bioanalysis and toxicokinetic analysis
  • Strong knowledge of IND, NDA, GxP requirements.
  • Excellent project and time management skills
  • Expertise in immunology, fibrosis, and metabolic disease drug development is a plus
  • A comprehensive understanding of physiology and understanding of underlying biologic phenomena
  • Proven strategic and operational leadership
  • Strong interpersonal skills, including the ability to gain credibility across functional lines
  • Demonstrated ability to develop strong relationships with key internal and external stakeholders
  • Superior collaboration, coordination, organization and presentation skills, both written and oral
  • Ability to communicate complex technical information to internal personnel and external stakeholders

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives.  In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing oral integrin therapies.  Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Dr. Timothy A. Springer, Morphic has developed an exclusive MInT platform that facilitates the rapid discovery of clinical candidates.  Morphic was created in 2015 and raised $51.5M in 2016 from top tier investors.  In 2018, Morphic Therapeutic completed an $80 million Series B financing round and formed a collaboration with Abbvie Inc. focused on the exploration of TGF-β biology in fibrotic diseases. In 2019 Morphic formed a collaboration with Janssen Biotech, a Johnson and Johnson company to explore the potential of integrin inhibitors and activators in multiple diseases. On Jun. 26, 2019 Morphic announced the pricing of its upsized initial public offering of 6,000,000 shares of its common stock at a price to the public of $15.00 per share. The shares are trading on The Nasdaq Global Market under the symbol “MORF.”

Currently, we are advancing both partnered and fully-owned oral integrin therapeutic candidates into the clinic.  Integrin dysregulation is involved in multiple diseases that span, including inflammation, fibrosis, vascular diseases, and cancer. Our immediate focus is on the areas where the clinical activity of antibody inhibitors of integrins is precedented, thus enabling a rapid path to clinical proof-of-concept.

The Morphic Therapeutic office is located in the AstraZeneca BioHub in Waltham, MA.  We are seeking a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Job description

The Associate Director of Toxicology will provide operational support and guidance for the safety assessment of multiple programs from late discovery through the clinical stage. The successful candidate will work in a highly collaborative team environment applying her/his toxicology experience towards the advancement of small molecule drug candidates. This individual will play a critical role in the design, implementation, and careful monitoring of toxicology studies conducted by contract laboratories She/he will work together with a network of experts to interpret and communicate the findings both in oral and written form to the internal and external stakeholders. She/he will be working under company Standard Operating Procedures relevant to the job function. The ideal candidate will be a self-starter, who will strive in a fast-paced, collaborative, learning environment. She/he will report to the Vice President, Toxicology and Bioanalysis.

Responsibilities

  • Provide expert support and guidance on safety assessments to the internal cross-functional project teams
  • Design and execute toxicology studies, based on off- and on-target safety profiles of the candidate drugs
  • Incorporate toxicology into medicine development plans to accelerate clinical development
  • Oversee contracting, protocol development, and execution of the toxicology studies conducted at contract laboratories
  • Monitor toxicology studies for appropriate conduct, and timely execution; audit raw data for accuracy, review draft reports and finalize them as submission-ready documents for regulatory authorities
  • Proactively respond to study issues, manage timeline changes, and develop and communicate the solutions to the project team
  • Author and review toxicology and safety pharmacology sections of relevant regulatory documents
  • Act as a key scientific resource, providing knowledge and expertise to cross-functional project teams

Qualifications

  • Advanced degree in Toxicology, Pathology, Pharmacology, DABT certification; diplomate ACVP is a plus
  • 10+ years of experience in toxicology in small molecule drug development in the biopharma industry
  • Solid understanding of small molecule drug development with the focus on early development
  • Strong knowledge of IND, IMPD, CTA, and GLP requirements. Excellent project and time management skills
  • Extensive experience managing toxicology studies conducted at Contract Research Organizations
  • Expertise in the bioanalytical and toxicokinetic analysis. Experience in immunology or fibrosis diseases
  • Strong interpersonal skills, including the ability to gain credibility and work across functional lines
  • Superior attention to detail, coordination, organization and collaboration, presentation skills, both written and oral
  • Ability to communicate complex technical information to internal personnel and external stakeholders

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives.  In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

Click here to apply now!

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing oral integrin therapies. Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Dr. Timothy A. Springer, Morphic has developed an exclusive MInT platform that facilitates the rapid discovery of clinical candidates. Morphic was created in 2015 and raised $51.5M in 2016 from top tier investors. In 2018, Morphic Therapeutic completed an $80 million Series B financing round and formed a collaboration with Abbvie Inc. focused on the exploration of TGF-β biology in fibrotic diseases. In 2019 Morphic formed a collaboration with Janssen Biotech, a Johnson and Johnson company to explore the potential of integrin inhibitors and activators in multiple diseases. On Jun. 26, 2019 Morphic announced the pricing of its upsized initial public offering of 6,000,000 shares of its common stock at a price to the public of $15.00 per share. The shares are trading on The Nasdaq Global Market under the symbol “MORF”.

Currently, we are advancing both partnered and fully-owned novel oral integrin therapeutic candidates into the clinic. Integrin dysregulation is involved in multiple diseases, including inflammation, fibrosis, vascular diseases, and cancer. Our immediate focus is on the areas where the clinical activity of antibody inhibitors of integrins is precedented, thus enabling a rapid path to clinical proof-of-concept.

The Morphic Therapeutic office is located in the AstraZeneca BioHub in Waltham, MA. We are seeking a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Description

We are seeking a dynamic and talented professional for the role of Administrative Assistant supporting designated leadership and senior management. This position provides high-level administrative support and involves scheduling meetings, booking travel, keeping track of time, expenses and invoices, supporting project processes and internal business initiatives, and keeping up with the fast pace of our senior team members. The Administrative Assistant is responsible for identifying and managing the right priorities and processes to ensure our team has what they need to seamlessly meet the project deadlines. Administrative Assistants actively participates in office life, are flexible and willing to help all fellow team members, and collaborate across functions.

Responsibilities

  • Proactively manage calendar and scheduling for complex internal and external meetings, conferences and professional engagements for senior management team with an understanding of business priorities; proactively manages extremely complex calendars
  • Compose and prepare correspondences, documents, presentation materials and reports
  • Coordinate all domestic and international travel arrangements end to end including air, hotel and car service; anticipate and proactively handle last minute adjustments or changes
  • Prepare and process expense reports with attention to accuracy, timelines and compliance with Corporate policy requirements; track payments and troubleshoot issues
  • Assist in planning and coordinating logistics for small to large scale meetings and events; prepare agendas • Coordinate logistics such as conference rooms, video or teleconference details, AV, lunches etc.
  • Order catering items for team meetings; assist w/set-up and clean-up as needed
  • Order office supplies for team
  • Assist team w/visitor badge requests as needed (coordinate w/team regarding employees or clients visiting offices (and ALL accommodations)

Education/Experience:

  • Bachelor’s degree in Business Management or a related filed.
  • Minimum of 3 years of experience in a providing senior management level support, preferably in the biotech industry.

Required Qualifications and Skills:

  • Demonstrated ability to handle diverse, competing priorities in a highly efficient and timely manner
  • Self-starter and fast learner with the ability to ‘hit the ground running’, setting the standard for meeting and exceeding expectations
  • Experience working in a dynamic, fast-paced and always evolving environment
  • Excellent communication (verbal and written) and interpersonal skills along with the ability to handle sensitive and confidential information appropriately; Ability to communicate effectively with all levels of personnel both internally and externally
  • Highly proficient computer and presentation preparation skills, including Microsoft Office (Outlook, Word, PowerPoint, Excel) and SharePoint;
  • Excellent organizational skills with proven success in ability to prioritize and manage multiple projects simultaneously; meet and anticipate frequent deadlines and manage situations through from start to finish
  • Flexibility to work before and after normal business hours, as needed, to respond to business critical needs
  • The drive for self-development, the ability to collaborate, and an action-oriented work ethic

 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives.  In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.