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About Morphic Therapeutic

Morphic Therapeutic is a biopharmaceutical company developing a new generation of oral integrin therapies for the treatment of serious chronic diseases, including autoimmune, cardiovascular and metabolic diseases, fibrosis and cancer. In collaboration with AbbVie, Janssen and Schrödinger, Morphic is advancing its pipeline and discovery activities using its proprietary MInT technology platform which leverages the Company’s unique understanding of integrin structure and biology. For more information, visit www.morphictx.com.

Morphic is advancing both partnered and fully-owned oral integrin therapeutic candidates with the initial clinical trials beginning in the 2020. Our immediate focus is on the areas where the clinical activity of antibody inhibitors of integrins is precedented, thus enabling a rapid path to clinical proof-of-concept. Morphic Therapeutic is located in the AstraZeneca BioHub in Waltham, MA. We are seeking a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Job Description:

The Director, Pharmacovigilance will report to the Chief Medical Officer and will be a key member of Morphic clinical team.  The individual will lead and manage the Pharmacovigilance function for all product candidates globally, act as a key contributor to clinical development plans, and manage all relevant reporting to global health regulatory authorities.

Essential Job Functions:

  • Manages and oversees the company’s drug safety and pharmacovigilance process.
  • Manages compliance with standard operating procedures, regulatory safety, and pharmacovigilance in compliance with national and international regulations, such as the Food and Drug Administration (FDA) and World Health Organization, global, regional and country regulations for the reporting of adverse events to regulatory agencies.
  • Coordinates the development of guidelines and ensures the uniform and timely processing of adverse event reports.
  • Interfaces with internal and external collaborators to develop programs and processes to meet regulatory reporting requirements
  • With CMO, facilitates PI interactions as needed to review adverse events, including potential SUSARs, on an as-needed basis
  • Drafts, finalizes, and implements safety data sharing and safety management plans on all Morphic-sponsored studies with and for all clinical CROs working with Morphic.
  • Oversees the development and preparation of reports for company management as well as external regulatory agencies.
  • Manages and conducts ongoing safety surveillance on company products.
  • Oversees the preparation of new drug application safety updates, investigational new drug safety reports, investigator communications, product labeling/package inserts and other reports, as necessary.
  • Participates in oversight of ongoing clinical trials and in the preparation of study concepts, synopses, protocols and key regulatory documents (e.g. IB updates, DSURs, new drug applications[NDAs]) with respect to drug safety.

Qualification:

Required

  • PharmD, RN or other relevant clinical discipline.
  • 8+ years of related experience in pharmaceutical or biotech industry, or equivalent.
  • Strong ability to work collaboratively in dynamic small teams of internal and external partners that are a part of a fast-paced environment
  • Excellent critical data analysis skills (clinical/systems/processes/compliance).
  • Attention to detail and the ability to work individually, within a multi-disciplinary team, as well as with external partners and vendors.
  • In-depth knowledge of US and international pharmacovigilance regulations, FDA requirements, international guidelines (ICH/CIOMS) with experience in their practical application.
  • In-depth understanding of pharmacovigilance processes, regulatory compliance, and standardization.
  • Pharmacovigilance data systems experience is required.

Desired

  • 3+ years of progressive clinical development experience, preferably in pharmacovigilance, at a pharmaceutical or biotechnology company
  • Broad experience in clinical trial design (phases 1 to 3) and clinical data interpretation
  • Working knowledge of FDA and EMA regulatory landscapes, GCP, and ICH guidelines

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives.  In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

Click Here to Apply Now!

About Morphic Therapeutic

Morphic Therapeutic  is a biopharmaceutical company developing a new generation of oral  integrin therapies for the treatment of serious chronic diseases,  including autoimmune, cardiovascular and metabolic diseases, fibrosis  and cancer. In collaboration with AbbVie, Janssen and Schrödinger,  Morphic is advancing its pipeline and discovery activities using its  proprietary MInT technology platform which leverages the Company’s  unique understanding of integrin structure and biology. For more  information, visit www.morphictx.com.

Morphic is advancing both  partnered and fully-owned oral integrin therapeutic candidates with the  initial clinical trials beginning in the 2020. Our immediate focus is on  the areas where the clinical activity of antibody inhibitors of  integrins is precedented, thus enabling a rapid path to clinical  proof-of-concept. Morphic Therapeutic is located in the AstraZeneca  BioHub in Waltham, MA. We are seeking a highly talented and motivated  individual to join our culture of teamwork, craftsmanship, tenacity,  compassion, and integrity.

Job Description:

Morphic Therapeutic is currently accelerating our oncology portfolio development and is seeking a (Executive/Senior) Medical Director to provide oncology clinical development and/or translational expertise. Reporting directly to the CMO, the (Executive/Senior) medical director will be responsible for leading the development and execution of the clinical trials in our oncology programs. The successful candidate will work closely with the team members & functions across the organization including our Discovery, Clinical and Regulatory groups as the company’s Oncology program is currently focused on research and early clinical development. This individual will partner with the CMO to lead external meetings including academic study investigators, advisory meetings with opinion leaders, and interactions with Health Authorities as needed.

Essential Job Functions:

• Initiating, communicating, and executing well-conceived clinical development plans in support of immuno-oncology Development priorities of Morphic

• Responsible for the strategic and operational medical input to the design, planning, initiation, completion, analysis, and reporting of clinical trials in the oncology/solid tumor therapeutic area

• Providing clinical input on all IND and preparation activities including data collection, database lock, analysis and write-up of biomarker and pharmacodynamic endpoints

• Communicating Morphic’s clinical development goals, clinical trial plans and data, as well as clinical program accomplishments to the external community, investigators, key opinion leaders and corporate partners

• Participating in, and provide clinical support to business development activities on an as-needed basis

• Perform medical review, assessment, and interpretation of all clinical efficacy/translational/safety data to be reported in clinical study reports to ensure that the data are correct and presented with the appropriate medical interpretation.

• Work closely with the CMO and other executive team members on broader strategy and development of the clinical development plans for various programs.

Successful candidates will have the following personal qualities & experiences:

• A physician scientist who enjoys and has been successful at working closely with discovery/biology teams to analyze and interpret preclinical data, and help to shape our oncology indication strategy from a clinical & preclinical point of view

• Experience in planning and executing clinical trials including FIH (i.e. Dose Escalation/Expansion Cohort studies) in immuno-oncology and solid tumor indications on either the study site or industry side

• Clinical experience in immuno-oncology patient care preferred

• Experience in negotiating clinical trial programs with regulatory authorities a plus

• Prior experience working in a small, fast-moving, entrepreneurial company a plus

• Demonstrated ability to collaborate successfully with multiple functions in a team environment

• Strong written and oral communication skills, including presentation skills

• Ability to analyze and interpret clinical and efficacy data and develop written reports and presentations of those data

Cultural Fit

Our culture is collaborative, one where people enjoy coming to work. We are a small, entrepreneurial company where everyone pitches in and works together to do whatever it takes to get things done. Our team is passionate, enthusiastic, and committed.

We have a fast-paced, high accountability environment. We have a flat organization, and our leaders lead through influence and interpersonal skills, not command and control. Everyone on the team, including our CEO, is an individual contributor.

We seek an individual for this position who shares our values and our enthusiasm about bringing new medicines to the patients and families that need them. We seek someone who will enjoy working in a small company environment and be motivated by the opportunity to directly influence and help shape the future direction and culture of our company.

Professional Qualifications:

Required

• M.D. or M.D./Ph.D. with experience in driving early clinical development within the adult oncology/solid tumor TA with a strong scientific background is required.

• A minimum of 3 years (>=5 years preferred) of clinical research experience in Oncology clinical development in University and/or pharmaceutical/ biotech industry is required.

• Expertise in the areas of drug development, operations, and strategic planning.

• Experience with preparing clinical sections to support IND submissions

• Excellent communication skills including experience presenting to a wide variety of audiences such as internal teams, medical and scientific communities.

• Approximately 25% of domestic and international travel (Post COVID-restrictions) will be required to attend key internal and relevant professional meetings.

Desired

• U.S. (or Foreign Equivalent) Board Certified in Oncology

• Solid tumor clinical development experience in the context of checkpoint inhibitor programs

• Deep knowledge of CPI resistance mechanisms

Morphic Therapeutic is an equal opportunity employer committed to  providing an environment that maximizes our employees’ development and  achievement goals. We strive to treat each employee as an individual, as  we seek to foster a spirit of teamwork to help change patients’ lives.  In addition to a competitive compensation and benefits package that  includes medical, dental and vision coverage, a 401K and a generous  vacation and holiday schedule.

Click Here to Apply Now!

About Morphic Therapeutic

Morphic Therapeutic   is a biopharmaceutical company developing a new generation of oral   integrin therapies for the treatment of serious chronic diseases,   including autoimmune, cardiovascular and metabolic diseases, fibrosis   and cancer. In collaboration with AbbVie, Janssen and Schrödinger,  Morphic is advancing its pipeline and discovery activities using its  proprietary MInT technology platform which leverages the Company’s  unique understanding of integrin structure and biology. For more information, visit www.morphictx.com.

Morphic is advancing both   partnered and fully-owned oral integrin therapeutic candidates with the   initial clinical trials beginning in the 2020. Our immediate focus is  on  the areas where the clinical activity of antibody inhibitors of   integrins is precedented, thus enabling a rapid path to clinical  proof-of-concept. Morphic Therapeutic is located in the AstraZeneca  BioHub in Waltham, MA. We are seeking a highly talented and motivated   individual to join our culture of teamwork, craftsmanship, tenacity,   compassion, and integrity.

Job Description:

The Bioanalytical Study Manager shares responsibilities for management of bioanalytical studies for preclinical, GLP, and clinical studies that generate pharmacokinetic and toxicokinetic concentration data for Morphic Therapeutic drug candidates. The candidate performs bioanalytical vendor management activities and works with the Associate Director, Bioanalytical to develop, validate and execute bioanalytical method creation and validation for studies as needed.

Essential Job Functions:

• Collaborate with DMPK, Clinical Development, and other functional groups to define and orchestrate bioanalytical support for team objectives

• Manage bioanalytical CROs to maintain timelines and data quality in support of bioanalytical work for early preclinical, GLP, and clinical phase studies

• Maintain vendor relationships and readiness through regular interactions, correspondence, and site visits

• Review and ensure the quality of CRO deliverables, including data sets, reports, plans, data transfer agreements and contracts

• Support Bioanalytical readiness for potential IND, NDA, and/or BLA submissions

Qualification:

Required

• Bachelor’s degree in Biology, Chemistry, or a related field

• 5+ years’ experience in Regulated Bioanalytical Sciences using LC-MS/MS for measurement of small molecules, including hands on experience

• Excellent written and verbal communication skills

• Bioanalytical expertise in small molecule LC-MS/MS

• Proficiency with computers and software relevant to bioanalytical sciences, including Excel, PowerPoint, cloud/server-based file sharing systems, LIMS, Analyst, etc.

• Familiarity with bioanalytical regulations and guidance including GLP, FDA, EMA, ICH

• Experience with bioanalytical vendor oversight from a sponsor perspective

• General understanding of drug discovery and development and the role bioanalysis plays

• Growth mindset, internally motivated, with impeccable integrity

Desired

• Project management experience and/or certification/training a plus

• Experience with non-compartmental analysis using Phoenix WinNonLin or similar is a plus

• Hands on experience with large molecule bioanalysis a plus

Morphic Therapeutic is an equal opportunity employer committed to  providing an environment that maximizes our employees’ development and  achievement goals. We strive to treat each employee as an individual,  as  we seek to foster a spirit of teamwork to help change patients’  lives.  In addition to a competitive compensation and benefits package  that  includes medical, dental and vision coverage, a 401K and a  generous  vacation and holiday schedule.

Click Here to Apply Now!

About Morphic Therapeutic

Morphic Therapeutic is a biopharmaceutical company developing a new  generation of oral integrin therapies for the treatment of serious  chronic diseases, including autoimmune, cardiovascular and metabolic  diseases, fibrosis and cancer. In collaboration with AbbVie, Janssen and  Schrödinger, Morphic is advancing its pipeline and discovery activities  using its proprietary MInT technology platform which leverages the  Company’s unique understanding of integrin structure and biology. For  more information, visit www.morphictx.com.

Morphic is advancing both partnered and fully-owned oral integrin  therapeutic candidates with the initial clinical trials beginning in the  2020. Our immediate focus is on the areas where the clinical activity  of antibody inhibitors of integrins is precedented, thus enabling a  rapid path to clinical proof-of-concept. Morphic Therapeutic is located  in the AstraZeneca BioHub in Waltham, MA. We are seeking a highly  talented and motivated individual to join our culture of teamwork,  craftsmanship, tenacity, compassion, and integrity.

 

Job Description: 

  • Morphic Therapeutic is seeking a Research Associate with in vitro and in vivo skills for pre-clinical research in I/O space. The candidate will join a dynamic, multi-disciplinary team of scientists, playing a key role to evaluate new immunotherapeutic strategies and drug candidates. The candidate is expected to be multi-tasking and able to execute experiments  with strong attention to detail. The candidate should be highly motivated, organized, flexible, excited to be in a lab-based role, and collaborate effectively in a team environment.

Essential Job Functions: 

  • Perform standard procedures in live rodent models, handling, dosing, genotyping
  • Tumor study monitoring, measurement, necropsy procedures, and downstream sample processing
  • Isolate and characterize different subsets of primary human and mouse immune cells
  • Perform mammalian cell culture, transfection, Western blot, q-PCR, multicolor flow cytometry, sorting, Elisa
  • Use  MSD, IncuCyte, and NanoString systems
  • Analyze experimental results for presentations to peers and management team

Qualification: 

  • B.S. or M.S. degree, prior experience working in an academic laboratory

Morphic Therapeutic is an equal opportunity employer committed to  providing an environment that maximizes our employees’ development and  achievement goals. We strive to treat each employee as an individual, as  we seek to foster a spirit of teamwork to help change patients’ lives.  In addition to a competitive compensation and benefits package that  includes medical, dental and vision coverage, a 401K and a generous  vacation and holiday schedule.

Click Here to Apply Now!

About Morphic Therapeutic

Morphic Therapeutic is a biopharmaceutical company developing a new  generation of oral integrin therapies for the treatment of serious  chronic diseases, including autoimmune, cardiovascular and metabolic  diseases, fibrosis and cancer. In collaboration with AbbVie, Janssen and  Schrödinger, Morphic is advancing its pipeline and discovery activities  using its proprietary MInT technology platform which leverages the  Company’s unique understanding of integrin structure and biology. For  more information, visit www.morphictx.com.

Morphic is advancing both partnered and fully-owned oral integrin  therapeutic candidates with the initial clinical trials beginning in the  2020. Our immediate focus is on the areas where the clinical activity  of antibody inhibitors of integrins is precedented, thus enabling a  rapid path to clinical proof-of-concept. Morphic Therapeutic is located  in the AstraZeneca BioHub in Waltham, MA. We are seeking a highly  talented and motivated individual to join our culture of teamwork,  craftsmanship, tenacity, compassion, and integrity.

Job Description:

The Associate Director of Toxicology will provide operational support and guidance for the safety assessment of multiple programs from late discovery through the clinical stage. The successful candidate will work in a highly collaborative team environment applying her/his toxicology experience towards the advancement of small molecule drug candidates. This individual will play a critical role in the design, implantation, and careful monitoring of toxicology studies conducted by contract laboratories. She/he will work together with a network of experts to interpret and communicate the findings both in oral and written form to the internal and external stakeholders. She/he will be working under company Standard Operating Procedures relevant to the job function . The ideal candidate will be a self-starter, who will strive for excellence in a fast-paced, collaborative, learning environment. She/he will report to the Vice President, Safety Assessment.

Essential Job Functions:

• Provide expert support and guidance on safety assessments to the internal cross-functional project teams

• Design and execute toxicology studies, based on off- and on-target safety profiles of candidate drugs

• Incorporate toxicology into development plans to support and accelerate clinical development

• Oversee contracting, protocol development and execution of toxicology studies conducted at contract laboratories

• Monitor toxicology studies for appropriate conduct and timely execution audit raw data for accuracy, review draft reports and finalize them as submission-ready documents for regulatory authorities

• Proactively respond to study issues, manage timeline changes, and develop and communicate the solutions to the project team

• Author and review toxicology and safety pharmacology sections of relevant regulatory documents

• Act as a key scientific resource, providing knowledge and expertise to cross-functional project teams

Qualification:

Required

• Advanced degree in toxicology, pharmacology, or pathology

• 10+ years of experience in toxicology in small molecule drug development in the biopharma industry

• Strong knowledge of IND, CTA and GLP requirements and ICH guidelines. Excellent project and time management skills

• Extensive experience managing toxicology studies conducted at Contract Research Organizations

Desired

• DABT certification, diplomate of ACVP is a plus

Morphic Therapeutic is an equal opportunity employer committed to  providing an environment that maximizes our employees’ development and  achievement goals. We strive to treat each employee as an individual, as  we seek to foster a spirit of teamwork to help change patients’ lives.  In addition to a competitive compensation and benefits package that  includes medical, dental and vision coverage, a 401K and a generous  vacation and holiday schedule.

Click Here to Apply Now!

About Morphic Therapeutic

Morphic Therapeutic is a biopharmaceutical company developing a new generation of oral integrin therapies for the treatment of serious chronic diseases, including autoimmune, cardiovascular and metabolic diseases, fibrosis and cancer. In collaboration with AbbVie, Janssen and Schrödinger, Morphic is advancing its pipeline and discovery activities using its proprietary MInT technology platform which leverages the Company’s unique understanding of integrin structure and biology. For more information, visit www.morphictx.com.

Morphic is advancing both partnered and fully-owned oral integrin therapeutic candidates with the initial clinical trials beginning in the 2020. Our immediate focus is on the areas where the clinical activity of antibody inhibitors of integrins is precedented, thus enabling a rapid path to clinical proof-of-concept. Morphic Therapeutic is located in the AstraZeneca BioHub in Waltham, MA. We are seeking a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

 

Essential Job Functions:

Responsibilities included but are not limited to:

· Use current and novel techniques to address questions of drug mechanism of action

· Design, develop and implement in vitro assays to address target and drug biology

· Develop and execute wide range of in vivo oncology models to evaluate activity of drug targets

· Perform mouse tumor studies, monitoring, necropsy procedures and downstream processing of samples

· Design and perform experiments to deliver pre-clinical data sets, including RNA-Seq, single-cell sequencing, cytokine, Nano-String and multicolor flow cytometry

· Execute experiments independently, troubleshoot as needed, interpret and discuss data

· Mentor junior colleagues

Qualifications:

Ph.D. degree in immunology, molecular biology or related fields and postdoctoral experience in an academic lab.

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

Click Here to Apply Now!

About Morphic Therapeutic

Morphic Therapeutic is a biopharmaceutical company developing a new  generation of oral integrin therapies for the treatment of serious  chronic diseases, including autoimmune, cardiovascular and metabolic  diseases, fibrosis and cancer. In collaboration with AbbVie, Janssen and  Schrödinger, Morphic is advancing its pipeline and discovery activities  using its proprietary MInT technology platform which leverages the  Company’s unique understanding of integrin structure and biology. For  more information, visit www.morphictx.com.

Morphic is advancing both partnered and fully-owned oral integrin  therapeutic candidates with the initial clinical trials beginning in the  2020. Our immediate focus is on the areas where the clinical activity  of antibody inhibitors of integrins is precedented, thus enabling a  rapid path to clinical proof-of-concept. Morphic Therapeutic is located  in the AstraZeneca BioHub in Waltham, MA. We are seeking a highly  talented and motivated individual to join our culture of teamwork,  craftsmanship, tenacity, compassion, and integrity.

Job Description:

We are looking for a highly energetic and organized individual to orchestra operations of the labs at Morphic Therapeutic. The successful candidate will assure a safe, compliant, and efficient laboratory. Must be self-motivated and able to effectively communicate with multiple lab members. Comfort working in a lab setting is essential.

Essential Job Functions:

Responsibilities include but are not limited to:

• Oversee the development, planning, and implementation of environmental, health and safety policies; develop procedures (chemical safety, shipping, IACUC, ergonomics, illness, and injury prevention, and building safety) used throughout the company.

• Ensure compliance with federal, state, and local regulations pertaining to environmental safety and handle all contact with appropriate agencies.

• Oversee licensed hazardous and radioactive waste disposal and monitors waste handling.

• Develop and oversees company training programs for employees in areas such as compliance training, lab/plant inspection, hazardous material handling, emergency response, industrial hygiene, and life safety.

• Be the point of contact for emergency personnel and manage workers compensation program administration.

• Ensure appropriate corrective action is taken where health and safety hazards exist.

• Select, develop, and evaluate personnel to ensure the efficient operation of the function.

• Collaborate with research leadership, researchers, and assistants.

• Orchestra lab safety and facilities in the company.

Qualification:

Required

• Familiarity with lab environment including laboratory safety protocols.

• 10+ years of laboratory experience in pharma or CRO.

• 8+ years in a supervisory or management role.

• Bachelor’s degree in life sciences field.

Morphic Therapeutic is an equal opportunity employer committed to  providing an environment that maximizes our employees’ development and  achievement goals. We strive to treat each employee as an individual, as  we seek to foster a spirit of teamwork to help change patients’ lives.  In addition to a competitive compensation and benefits package that  includes medical, dental and vision coverage, a 401K and a generous  vacation and holiday schedule.

Click Here to Apply Now!

About Morphic Therapeutic

Morphic Therapeutic is a biopharmaceutical company developing a new generation of oral integrin therapies for the treatment of serious chronic diseases, including autoimmune, cardiovascular and metabolic diseases, fibrosis and cancer. In collaboration with AbbVie, Janssen and Schrödinger, Morphic is advancing its pipeline and discovery activities using its proprietary MInT technology platform which leverages the Company’s unique understanding of integrin structure and biology. For more information, visit www.morphictx.com.

Morphic is advancing both partnered and fully-owned oral integrin therapeutic candidates with the initial clinical trials beginning in the 2020. Our immediate focus is on the areas where the clinical activity of antibody inhibitors of integrins is precedented, thus enabling a rapid path to clinical proof-of-concept. Morphic Therapeutic is located in the AstraZeneca BioHub in Waltham, MA. We are seeking a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity.

Job Description: 

Reporting to the Head of Clinical Operations, the Associate Director of Clinical Operations will be responsible for the implementation and conduct of clinical trials. These activities include site feasibility analysis and selection, vendor evaluation, direct oversight of study conduct, contract research organizations (CROs) and vendors, management of the relationships with clinical sites, and study start-up and closeout activities. She/he will be accountable for the completion of the clinical activities on time and within budget. She/he will ensure timely collection and validation of all the study-related data and documentation. The successful candidate will work collaboratively with the members of the research and development organization in the Company.

Essential Responsibilities:

• Evidence of thorough understanding of the processes required to operationally execute clinical trials to a high standard of excellence.

• Management of clinical operation activities from the study start-up to closeout, including providing appropriate oversight to any CRO executing on Morphic’s clinical studies.

• Reviews and/or manages the review of study documentation, including but not limited to the protocol, informed consent forms, monitoring plan, and study manuals.

• Facilitates site feasibility and selection process.

• May serve as the vendor and/or site contact in managing clinical protocol execution.

• Establishes study milestones and ensures accurate tracking and reporting of study metrics and timelines.

• Responsible for trial adherence to ICH/GCP/Federal and local regulations and Company-specific SOPs.

• Ability to identify study risks impacting clinical quality and support measures to mitigate such risks.

• Reviews and ensures completeness of the Trial Master File (TMF).

• Facilitates and responds to Quality Assurance and regulatory authority(ies) inspection audits.

• Proactively identifies and communicates the study-related problems and proposes solutions.

• Develops and maintains strong, collaborative relationships with vendors, CROs, clinical site personnel.

• Collaborates effectively with the members of the cross-function project teams.

Qualifications:

Required:

· Advanced degree (MS, PharmD, PhD, or equivalent professional); bachelor degree in life sciences or health-related field will be considered.

· Minimum of 7 years of clinical research experience, including 3+ years in direct trial management experience, with 5+ years in a pharmaceutical or biopharmaceutical environment.

· Experience in activities related to process improvement, SOP development and review, and  study specific training management.

· Experience supporting response strategy for risk mitigations, audits, and regulatory      inspections using established risk management techniques (e.g., root cause analysis, CAPA).

· Prior experience identifying, selecting, and managing CROs.

· Experience with authoring study documents (e.g., ICF, patient-facing materials, etc.) and reviewing such materials.

· Ability to foster effective relationships with vendors, investigators, and colleagues.

· Ability to contribute technical expertise to the various aspects of the clinical study process.

· Knowledge of industry standards as applied to ICH guidelines, GCPs, CFR, and other relevant regulatory guidelines.

· Ability to assess complex issues and propose viable solutions.

· Exceptional organizational skills and ability to deal with competing priorities.

· Strong collaborative, communication, and interpersonal skills. Creative problem-solver.

· Proven ability to interact with medical personnel at the site level productively.

· Superior attention to detail, coordination, organizational, and time management skills.

· Excellent written and verbal communication and presentation skills.

· Willing to travel 20% of the time as necessary, both domestically and internationally.

Desired

  • Experience with global clinical studies in difficult to      recruit populations
  • Experience with autoimmune diseases, fibrotic diseases,      and cancer.
  • Experience in institutional review board (IRB), ethics      committee (EC), and regulatory submissions
  • Experience with orphan drug designations and pediatric      plans.

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K, and a generous vacation and holiday schedule.

Click Here to Apply Now!

About Morphic Therapeutic

Morphic Therapeutic  is a biopharmaceutical company developing a new generation of oral  integrin therapies for the treatment of serious chronic diseases,  including autoimmune, cardiovascular and metabolic diseases, fibrosis  and cancer. In collaboration with AbbVie, Janssen and Schrödinger,  Morphic is advancing its pipeline and discovery activities using its  proprietary MInT technology platform which leverages the Company’s  unique understanding of integrin structure and biology. For more  information, visit www.morphictx.com.

Morphic is advancing both  partnered and fully-owned oral integrin therapeutic candidates with the  initial clinical trials beginning in the 2020. Our immediate focus is on  the areas where the clinical activity of antibody inhibitors of  integrins is precedented, thus enabling a rapid path to clinical proof-of-concept. Morphic Therapeutic is located in the AstraZeneca  BioHub in Waltham, MA. We are seeking a highly talented and motivated  individual to join our culture of teamwork, craftsmanship, tenacity,  compassion, and integrity.

Job Description:

Morphic Therapeutic is seeking a Research Associate with in vitro and in vivo skills for immunology, pre-clinical research in the areas of inflammation and autoimmunity. The successful candidate will join a dynamic, multi-disciplinary team of scientists, playing a key role to evaluate new immunotherapeutic strategies and drug candidates. The candidate is expected to be multi-tasking and able to execute experiments with strong attention to detail under supervision. The candidate should have high dexterity, be highly motivated, organized, creative and flexible, and collaborate effectively in a team environment.

Responsibilities include but are not limited to:

• Perform standard procedures in live rodent models

• Animal study monitoring, necropsy procedures, and downstream processing of samples

• Isolate and characterize different subsets of primary human and mouse immune cells

• Perform mammalian cell culture, transfection, Western blot, ELISA, RT-PCR, and multicolor flow cytometry

• Perform mechanistic studies to characterize the cellular pathways impacted by inhibition of integrin targets

• Analyze experimental results for presentations to peers and management

Qualifications:

B.Sc. degree with industry or academic experience in biology, immunology, or related field.

Required qualifications and skills:

• In vivo skills including routine animal handling

• Basic lab experience in life sciences, in vitro or in vivo

• Background in immunology, cell biology, biochemistry

• Demonstrated ability for multi-tasking and high productivity

• Ability to independently follow Standard Operating Procedures (SOPs)

• Fast learner and show curiosity in new techniques

• Excited to be in a lab-based role

Preferred skills:

• Hands-on experience with molecular and cell biology methodologies and cellular immunology

• Experience with culturing mammalian cells

• Prior experience monitoring in vivo disease models

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.